Interactions between lonidamine and β- or hydroxypropyl-β-cyclodextrin

被引：15
|
作者：
Palmieri, GF
Wehrlé, P
Martelli, S
机构：
[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy
[2] Fac Pharm Strasbourg, Lab Pharmacotech, F-67401 Illkirch Graffenstaden, France
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 07期
关键词：
D O I：
10.3109/03639049809082367
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The possibility of obtaining inclusion complexes between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin have been evaluated by phase solubility diagram, differential scanning calorimetry (DSC), and x-ray diffractometry. The applied complexation methods were spray-drying, kneading, and solid dispersion. DSC and x-ray analyses of the powders revealed an external interaction between lonidamine and cyclodextrins. Dissolution profiles of the obtained powders were also studied to define the most appropriate preparation method and molar ratio to use in attempts to increase lonidamine water solubility.
引用
收藏
页码：653 / 660
页数：8
相关论文
共 50 条
  • [1] Force Field Parameterization for the Description of the Interactions between Hydroxypropyl-β-Cyclodextrin and Proteins
    Arsiccio, Andrea
    Rospiccio, Marcello
    Shea, Joan-Emma
    Pisano, Roberto
    JOURNAL OF PHYSICAL CHEMISTRY B, 2021, 125 (27): : 7397 - 7405
  • [2] PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY AVOBENZONE WITH β-CYCLODEXTRIN, HYDROXYPROPYL-β-CYCLODEXTRIN AND HYDROXYPROPYL-α-CYCLODEXTRIN
    Sbora, Raluca
    Budura, Emma Adriana
    Nitulescu, George Mihai
    Balaci, Teodora
    Lupuleasa, Dumitru
    FARMACIA, 2015, 63 (04) : 548 - 555
  • [3] Enantioselective inclusion between terbutaline enantiomers and hydroxypropyl-β-cyclodextrin
    Kim, KH
    Park, YH
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 175 (02) : 247 - 253
  • [4] Inclusion complexes of fluorofenidone with β-cyclodextrin and hydroxypropyl-β-cyclodextrin
    Wang, Shengfeng
    Ding, Yanfei
    Yao, Yao
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2009, 35 (07) : 808 - 813
  • [5] Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-β-cyclodextrin
    Scalia, Santo
    Tursilli, Rosanna
    Sala, Nicoletta
    Iannuccelli, Valentina
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 320 (1-2) : 79 - 85
  • [6] The pH-dependent complexation between risperidone and hydroxypropyl-β-cyclodextrin
    M. Jug
    I. Kos
    M. Bećirević-Laćan
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 64 : 163 - 171
  • [7] The pH-dependent complexation between risperidone and hydroxypropyl-β-cyclodextrin
    Jug, M.
    Kos, I.
    Becirevic-Lacan, M.
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2009, 64 (1-2) : 163 - 171
  • [8] Thermodynamics of the interaction between hydroxypropyl-α-cyclodextrin and alkanols in aqueous solutions
    Vega-Rodriguez, A
    Piñeiro, A
    Perez-Casas, S
    THERMOCHIMICA ACTA, 2003, 405 (01) : 109 - 115
  • [9] Spectroscopic investigations on the inclusion interaction between hydroxypropyl-β-cyclodextrin and bupropion
    Misiuk, Wieslawa
    Zalewska, Magdalena
    JOURNAL OF MOLECULAR LIQUIDS, 2011, 159 (03) : 220 - 225
  • [10] Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin
    CHEN Yue 1
    2. Institute of Frontier Medical Science
    3. Center of Drug Discovery
    ChemicalResearchinChineseUniversities, 2005, (06) : 749 - 752
12345