New 5-modified 2′-deoxyuridine derivatives: synthesis and antituberculosis activity

被引：6

作者：

Shmalenyuk, E. R. ^{[1
]}

Karpenko, I. L. ^{[1
]}

Chernousova, L. N. ^{[2
]}

Chizhov, A. O. ^{[3
]}

Smirnova, T. G. ^{[2
]}

Andreevskaya, S. N. ^{[2
]}

Alexandrova, L. A. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Russian Acad Med Sci, Cent TB Res Inst, Moscow 107564, Russia

[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

nucleosides; 2 '-deoxyuridine; synthesis; inhibitor; antimycobacterial activity; tuberculosis; Mycobacterium tuberculosis; TUBERCULOSIS; C5;

D O I：

10.1007/s11172-014-0572-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New 2'-deoxyuridine derivatives containing long-chain hydrophilic substituents or hydrophilic groups at the 5 position of uracil were synthesized. 5-[4-(2-Carboxyethylcarbonylamino)-butyloxymethyl]-2'-deoxyuridine completely inhibits the growth of Mycobacterium tuberculosis at a concentration of 50 mu g mL(-1). However, oligo(ethylene glycol) derivatives do not exhibit activity even at high concentrations.

引用

页码：1197 / 1200

页数：4

共 50 条

[21] Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives
Gong, Jing-Xu
He, Ya
Cui, Zhen-Lin
Guo, Yue-Wei
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2016, 191 (07) : 1036 - 1041
[22] Synthesis of some chalcones derivatives series and their antituberculosis activity
Noviany, Noviany
Osman, Hasnah
Mohamad, Suriyati
Hadi, Sutopo
Satria, Heri
Buhani, Buhani
PURE AND APPLIED CHEMISTRY, 2024, 96 (03) : 351 - 368
[23] 5-Alkyloxymethyl Derivatives of 2ʹ-Deoxyuridine Bearing 2,4-Dinitrophenyl and Dansyl Groups: Synthesis and Antibacterial Activity
D. A. Makarov
I. A. Oskolsky
M. V. Jasko
P. N. Solyev
B. F. Vasilyeva
M. V. Demiankova
O. V. Efremenkova
S. N. Kochetkov
L. A. Alexandrova
Russian Journal of Bioorganic Chemistry, 2023, 49 : S1 - S7
[24] Synthesis and Antimycobacterial Activity of 2-(Phenyithio) benzoylarylhydrazone Derivatives
Almasirad, Ali
Samiee-Sadr, Somayeh
Shafiee, Abbas
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2011, 10 (04): : 727 - 731
[25] Synthesis of some novel hydrazone derivatives and evaluation of their antituberculosis activity
Ozdemir, Ahmet
Kaplancikli, Zafer Asim
Turan-Zitouni, Gulhan
Revial, Gilbert
MARMARA PHARMACEUTICAL JOURNAL, 2010, 14 (02) : 79 - 83
[26] Synthesis of novel [1,2]-diamines with antituberculosis activity
Meng, Qingyi
Luo, Huibing
Chen, Yilang
Wang, Tiancai
Yao, Qizheng
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (18) : 5372 - 5375
[27] New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties
Eswaran, Sumesh
Adhikari, Airody Vasudeva
Chowdhury, Imran H.
Pal, Nishith K.
Thomas, K. D.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (08) : 3374 - 3383
[28] Synthesis and antituberculosis activity of new fatty acid amides
Montes D'Oca, Caroline Da Ros
Coelho, Tatiane
Marinho, Tamara Germani
Lopes Hack, Carolina Rosa
Duarte, Rodrigo da Costa
da Silva, Pedro Almeida
Montes D'Oca, Marcelo Goncalves
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (17) : 5255 - 5257
[29] Quantum-chemical investigations of 5-bromo-2′-deoxyuridine derivatives with antiviral activity
Velkov, Zhivko A.
Velkov, Yasen Zh.
Tadjer, Alia V.
Stankova, Ivanka G.
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2006, 71 (05) : 691 - 697
[30] Design, Synthesis, and Biological Evaluation of New Cinnamic Derivatives as Antituberculosis Agents
De, Prithwiraj
Yoya, Georges Koumba
Constant, Patricia
Bedos-Belval, Florence
Duran, Hubert
Saffon, Nathalie
Daffe, Mamadou
Baltas, Michel
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (05) : 1449 - 1461

← 1 2 3 4 5 →