New 5-modified 2′-deoxyuridine derivatives: synthesis and antituberculosis activity

被引：6

作者：

Shmalenyuk, E. R. ^{[1
]}

Karpenko, I. L. ^{[1
]}

Chernousova, L. N. ^{[2
]}

Chizhov, A. O. ^{[3
]}

Smirnova, T. G. ^{[2
]}

Andreevskaya, S. N. ^{[2
]}

Alexandrova, L. A. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Russian Acad Med Sci, Cent TB Res Inst, Moscow 107564, Russia

[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

nucleosides; 2 '-deoxyuridine; synthesis; inhibitor; antimycobacterial activity; tuberculosis; Mycobacterium tuberculosis; TUBERCULOSIS; C5;

D O I：

10.1007/s11172-014-0572-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New 2'-deoxyuridine derivatives containing long-chain hydrophilic substituents or hydrophilic groups at the 5 position of uracil were synthesized. 5-[4-(2-Carboxyethylcarbonylamino)-butyloxymethyl]-2'-deoxyuridine completely inhibits the growth of Mycobacterium tuberculosis at a concentration of 50 mu g mL(-1). However, oligo(ethylene glycol) derivatives do not exhibit activity even at high concentrations.

引用

页码：1197 / 1200

页数：4

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