In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans

被引：37

作者：

Atai, Zahra ^{[1
]}

Atai, Mohammad ^{[2
]}

Amini, Javid ^{[3
]}

Salehi, Negar ^{[4
]}

机构：

[1] Kerman Univ Med Sci, Fac Dent, Dept Oral Med, Shafa Av, Kerman, Iran

[2] Iran Polymer & Petrochem Inst, Dept Polymer Sci, Tehran, Iran

[3] Islamic Azad Univ, Sci & Res Branch, Fac Basic Sci, Dept Microbiol, Tehran, Iran

[4] Rafsanjan Univ Med Sci, Fac Dent, Dept Oral Med, Rafsanjan, Iran

来源：

JOURNAL OF ORAL SCIENCE | 2017年 / 59卷 / 03期

关键词：

Candida albicans; chitosan; oral infection; denture stomatitis; DENTURE-RELATED STOMATITIS; WATER-SOLUBLE CHITOSAN; CHITIN; COLONIZATION; HYDROGELS; EFFICACY; DELIVERY;

D O I：

10.2334/josnusd.16-0295

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

This study investigated the antifungal effects of low-molecular-weight chitosan solution on Candida albicans in denture stomatitis in comparison with nystatin suspension. This randomized, single-blind clinical trial included 40 patients diagnosed with denture stomatitis. Patients were divided into two groups, wherein one was treated with chitosan and the other with nystatin for 2 weeks. Changes in the erythematous area were recorded during and after treatment. A palatal smear was obtained for each patient before and after treatment to determine the number of blastospores and mycelia of C. albicans. The results were compared using the Mann Whitney U test, revealing that the chitosan solution significantly decreased the erythematous surface area, burning sensation, time required for clinical improvement, and number of blastospores and mycelia. The antifungal efficacy of chitosan along with its inherent biocompatibility makes it a promising candidate for use as an antifungal mouthwash.

引用

页码：425 / 430

页数：6

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