Review of Ginseng Anti-Diabetic Studies

被引：100
作者：
Chen, Wei [1 ,2 ,3 ]
Balan, Prabhu [2 ,3 ]
Popovich, David G. [1 ]
机构：
[1] Massey Univ, Sch Food & Adv Technol, Palmerston North 4442, New Zealand
[2] Massey Univ, Riddet Inst, Palmerston North 4442, New Zealand
[3] Massey Univ, Alpha Massey Nat Nutraceut Res Ctr, Palmerston North 4442, New Zealand
来源：
MOLECULES | 2019年 / 24卷 / 24期
关键词：
ginseng; ginsenosides; anti-diabetes; insulin; blood glucose; KOREAN RED GINSENG; TYPE-2; DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; HIGH-FAT DIET; PANAX-GINSENG; INSULIN SENSITIVITY; DOUBLE-BLIND; PPAR-GAMMA; OXIDATIVE STRESS; CELL FUNCTION;
D O I：
10.3390/molecules24244501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng's anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.
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页数：16
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