Development of an injectable bioactive bone filler cement with hydrogen orthophosphate incorporated calcium sulfate

被引:15
|
作者
Sony, Sandhya [1 ]
Babu, S. Suresh [1 ]
Nishad, K. V. [1 ]
Varma, Harikrishna [1 ]
Komath, Manoj [1 ]
机构
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Bioceram Lab, Trivandrum 695012, Kerala, India
关键词
PHOSPHATE CEMENT; COMPOSITES; HYDROXYAPATITE; INJECTION; DELIVERY;
D O I
10.1007/s10856-014-5355-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Calcium sulfate cement (CSC) has emerged as a potential bone filler material mainly because of the possibility of incorporating therapeutic agents. Delivery of the cement through a needle or cannula will make it more useful in clinical applications. However, it was not possible to make CSC injectable because of the inherent lack of viscosity. The present work demonstrates the design development of a viscous and fully-injectable CSC by incorporating hydrogen orthophosphate ions, which does not hamper the biocompatibility of the material. The effect of addition of hydrogen orthophosphate on the rheological properties of the CSC paste was studied using a custom made capillary rheometer. The physicochemical changes associated with cement setting process were examined using X-ray diffraction and Fourier transform infrared spectroscopy and the thermal changes were measured through isothermal differential scanning calorimetry. Micromorphological features of different compositions were observed in environmental scanning electron microscopy and the presence of phosphate ions was identified with energy dispersive X-ray spectroscopic analysis and inductively coupled plasma-optical emission spectroscopy. The results indicated that HPO42- ions have profound effects on the rheological properties and setting of the CSC paste. Significant finding is that the HPO42- ions are getting substituted in the calcium sulfate dihydrate crystals during setting. The variations of setting time and compressive strength of the cement with the additive concentration were investigated. An optimum concentration of 2.5 % w/w gave a fully-injectable cement with clinically relevant setting time (below 20 min) and compressive strength (12 MPa). It was possible to inject the optimised cement paste from a syringe through an 18-gauge needle with thumb pressure. This cement will be useful both as bone filler and as a local drug delivery medium and it allows minimally invasive bone defect management.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 50 条
  • [21] An injectable porous bioactive magnesium phosphate bone cement foamed with calcium carbonate and citric acid for periodontal bone regeneration
    Wang, Jiawen
    Cheng, Ziqing
    Chen, Duanjing
    Li, Guangyue
    Chen, Jie
    Wang, Kai
    Xu, Ling
    Huang, Jiao
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2023, 142
  • [22] In vivo performance of an injectable biphasic calcium phosphate bone filler
    Layrolle, P.
    Baroth, S.
    Goyenvalle, E.
    Aguado, E.
    Moreau, F.
    Daculsi, G.
    BIOCERAMICS 21, 2009, 396-398 : 583 - 586
  • [23] In vivo performance of an injectable biphasic calcium phosphate bone filler
    Layrolle, P.
    Baroth, S.
    Goyenvalle, E.
    Aguado, E.
    Moreau, F.
    Daculsi, G.
    Key Engineering Materials, 2009, 396-398 : 583 - 586
  • [24] An injectable bone void filler cement based on Ca-aluminate
    Axén, N
    Persson, T
    Björklund, K
    Engqvist, H
    Hermansson, L
    BIOCERAMICS, VOL 16, 2004, 254-2 : 265 - 268
  • [25] Fabrication of Injectable Calcium Sulfate Bone Graft Material
    He, Yongqiang
    Gao, Jianping
    Li, Xiulan
    Ma, Zhiqing
    Zhang, Yang
    Li, Min
    Zhang, Yongli
    Wang, Xiaodong
    Qiu, Haixia
    Liu, Yu
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2010, 21 (10) : 1313 - 1330
  • [26] Development of injectable chitosan/biphasic calcium phosphate bone cement andin vitroandin vivoevaluation
    Rattanachan, Sirirat T.
    Srakaew, Nuan La-ong
    Thaitalay, Paritat
    Thongsri, Oranich
    Dangviriyakul, Rawee
    Srisuwan, Sawitri
    Suksaweang, Sanong
    Widelitz, Randell B.
    Chuong, Cheng-Ming
    Srithunyarat, Thanikul
    Kampa, Naruepon
    Kaenkangploo, Duangdaun
    Hoisang, Somphong
    Jittimanee, Suphattra
    Wipoosak, Piyasak
    Kamlangchai, Phanthit
    Yongvanit, Karn
    Tuchpramuk, Pongsatorn
    BIOMEDICAL MATERIALS, 2020, 15 (05)
  • [27] Factors influencing the compressive strength of an injectable calcium sulfate–hydroxyapatite cement
    M. Nilsson
    L. Wielanek
    J.-S. Wang
    K. E. Tanner
    L. Lidgren
    Journal of Materials Science: Materials in Medicine, 2003, 14 : 399 - 404
  • [28] Injectable and bioactive bone cement with moderate setting time and temperature using borosilicate bio-glass-incorporated magnesium phosphate
    Li, Chen
    Hao, Wenna
    Wu, Chunxuan
    Li, Wenchao
    Tao, Jun
    Ai, Fanrong
    Xin, Hongbo
    Wang, Xiaolei
    BIOMEDICAL MATERIALS, 2020, 15 (04)
  • [29] Bioactive bone cement: Effect of filler size on mechanical properties and osteoconductivity
    Shinzato, S
    Nakamura, T
    Kokubo, T
    Kitamura, Y
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2001, 56 (03): : 452 - 458
  • [30] Characterization of an alpha-Calcium Sulfate Hemihydrates/alpha-Tricalcium Phosphate Combined Injectable Bone Cement
    Yang, Dicheng
    Yan, Yinan
    Liu, Xunwei
    Wang, Ping
    Huang, Gang
    Xu, Guohua
    Sun, Gang
    He, Dannong
    ACS APPLIED BIO MATERIALS, 2018, 1 (03): : 768 - 776