The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum

被引：37
作者：
Day, JR
Frank, AT
O'Callaghan, JP
Jones, BC
Anderson, JE
机构：
[1] Ctr Dis Control, NIOSH, Morgantown, WV 26505 USA
[2] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA
来源：
EXPERIMENTAL NEUROLOGY | 1998年 / 151卷 / 02期
基金：
美国国家科学基金会;
关键词：
GFAP; astrocytes; testosterone; aging; cerebellum; rat;
D O I：
10.1006/exnr.1998.6801
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Testosterone reversed the age-related increase in glial fibrillary acidic protein (GFAP) in the male rat cerebellum, a brain region not generally associated with gonadal steroid hormone sensitivity. This supports the hypothesis that a decrease in circulating testosterone contributes to age-related increase in GFAP. These data also suggest that reductions in circulating gonadal steroids during aging could render the brain more susceptible to neurodegeneration and that hormone replacement therapy might have value in neurodegenerative disease intervention. (C) 1998 Academic Press.
引用
收藏
页码：343 / 346
页数：4
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