Human Herpes Simplex Virus: Life Cycle and Development of Inhibitors

被引：123

作者：

Kukhanova, M. K. ^{[1
]}

Korovina, A. N. ^{[1
]}

Kochetkov, S. N. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2014年 / 79卷 / 13期

基金：

俄罗斯基础研究基金会;

关键词：

HSV; herpes simplex; life cycle; replication; drugs; mutations; resistance; TYPE-1; DNA-POLYMERASE; HELICASE-PRIMASE INHIBITORS; NUCLEAR-LOCALIZATION SIGNAL; GUINEA-PIG MODEL; THYMIDINE KINASE; VIRAL REPLICATION; C-TERMINUS; IN-VITRO; HERPES-SIMPLEX-VIRUS-1; DNA; ANTIHERPESVIRUS ACTIVITY;

D O I：

10.1134/S0006297914130124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

引用

页码：1635 / 1652

页数：18

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