Cognitive dysmetria as an integrative theory of schizophrenia: A dysfunction in cortical subcortical-cerebellar circuitry?

被引：919

作者：

Andreasen, NC ^{[1
]}

Paradiso, S ^{[1
]}

O'Leary, DS ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Mental Hlth Clin Res Ctr, Iowa City, IA 52242 USA

来源：

SCHIZOPHRENIA BULLETIN | 1998年 / 24卷 / 02期

关键词：

cognitive dysmetria; cerebellum; thalamus; prefrontal cortex;

D O I：

10.1093/oxfordjournals.schbul.a033321

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been replaced by models that postulate a disruption in parallel distributed or dynamic circuits. Based on empirical data derived from both magnetic resonance and positron emission tomography, we have developed a model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum, A disruption in this circuitry produces "cognitive dysmetria," difficulty in prioritizing, processing, coordinating, and responding to information. This "poor mental coordination" is a fundamental cognitive deficit in schizophrenia and can account for its broad diversity of symptoms.

引用

页码：203 / 218

页数：16

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