Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis

被引：58

作者：

Guenat, David ^{[1
,2
,3
]}

Hermetet, Francois ^{[4
]}

Pretet, Jean-Luc ^{[1
,2
]}

Mougin, Christiane ^{[1
,2
]}

机构：

[1] Univ Bourgogne Franche Comte, LabEx LipSTIC ANR LABX 11 0021, EA3181, Rue Ambroise Pare, F-25000 Besancon, France

[2] CHRU, CNR Papillomavirus, Blvd Alexandre Fleming, F-25000 Besancon, France

[3] Stanford Univ, Stanford Canc Inst, Div Oncol, Dept Med, Stanford, CA 94305 USA

[4] Univ Bourgogne Franche Comte, Fdn Cooperat Sci Bourgogne Franche Comte, LabEx LipSTIC ANR LABX 11 0021, INSERM LNC UMR1231, F-21000 Dijon, France

来源：

VIRUSES-BASEL | 2017年 / 9卷 / 08期

关键词：

exosomes; microvesicles; apoptotic bodies; papillomavirus; horizontal gene transfer; cell-to-cell communication; carcinogenesis; TUMOR-DERIVED EXOSOMES; HUMAN-PAPILLOMAVIRUS E6; HORIZONTAL TRANSFER; EPITHELIAL-CELLS; APOPTOTIC CELLS; E7; ONCOPROTEINS; CANCER CELLS; STEM-CELLS; DNA; MICROVESICLES;

D O I：

10.3390/v9080211

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and MVs are garnering increasing attention because of their ability to participate in cellular communication or transfer of bioactive molecules (mRNAs, microRNAs, DNA and proteins) between neighboring cancerous or normal cells, and to contribute to human cancer progression. Malignant traits can also be transferred from apoptotic cancer cells to phagocytizing cells, either professional or non-professional. In this review, we focus on Exos and ABs and their relationship with human papillomavirus (HPV)-associated tumor development. The potential implication of EVs as theranostic biomarkers is also addressed.

引用

页数：17

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