Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

被引：38

作者：

Wong, Jia Hui ^{[1
]}

Barron, Anna M. ^{[1
]}

Abdullah, Jafri Malin ^{[2
,3
]}

机构：

[1] Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Neurobiol Aging & Dis Lab, Singapore, Singapore

[2] Univ Sains Malaysia, Sch Med Sci, Dept Neurosci, Kota Baharu, Kelantan, Malaysia

[3] Univ Sains Malaysia, Sch Med Sci, Brain & Behav Cluster & Dept Neurosci, Kota Baharu, Kelantan, Malaysia

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

medicinal plants; neuroprotection; mitochondria; neurodegeneration; centella asiatica (L; ) Urb; antioxidative; mitoprotective; CEREBRAL-ISCHEMIA-REPERFUSION; SPATIAL WORKING-MEMORY; MITOCHONDRIAL DYSFUNCTION; PENTACYCLIC TRITERPENE; LEAF EXTRACT; SUCCINATE-DEHYDROGENASE; STANDARDIZED EXTRACT; COGNITIVE DEFICITS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;

D O I：

10.3389/fphar.2021.687935

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. Centella asiatica (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past in vivo and in vitro studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer's disease and Parkinson's disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

引用

页数：9

共 124 条

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