Epidemiological characterization of respiratory tract infections caused by Mycoplasma pneumoniae during epidemic and post- epidemic periods in North China, from 2011 to 2016

被引:23
作者
Qu, Jiuxin [1 ,2 ]
Yang, Chunxia [2 ]
Bao, Fang [3 ]
Chen, Shuyan [4 ]
Gu, Li [2 ]
Cao, Bin [5 ]
机构
[1] Third Peoples Hosp Shenzhen, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
[2] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Pediat, Beijing, Peoples R China
[4] Third Peoples Hosp Shenzhen, Dept Clin Trial, Shenzhen, Guangdong, Peoples R China
[5] China Japan Friendship Hosp, Dept Resp & Crit Care Med, Clin Microbiol & Infect Dis Lab, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Mycoplasma pneumoniae; Respiratory tract infection; Epidemic; Post-epidemic; Epidemiology; COMMUNITY-ACQUIRED PNEUMONIA; NATIONWIDE SURVEILLANCE; MACROLIDE RESISTANCE; PREVALENCE; DIAGNOSIS; OUTBREAK; CHILDREN; ADULT; PCR;
D O I
10.1186/s12879-018-3250-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Mycoplasma pneumoniae (M. pneumoniae) is a commonly causative pathogen for respiratory tract infections (RTIs) in humans. The epidemiological features of M. pneumoniae infections during post-epidemic, including age distribution and the seasonality of the patients, are not well investigated. Methods: We retrospectively analyzed the clinical data of 7835 consecutive RTIs patients (3852 adults and 3983 children) who visited a teaching hospital, and defined an epidemic (2011-2013) and a post-epidemic period (2014-2016). M. pneumoniae was detected by fluorescence-quantatitive PCR in respiratory samples. Informed consent was obtained by all adults and the legal representatives of patients aged < 18 years, and the study was approved by Institutional Review Board of Beijing Chao-Yang Hospital (project approval number 10-KE-49). Results: The median (IQR) age was 16 (53) years (range < 0-105 years). The M. pneumoniae positive rate was 14.4% (21. 2%, epidemic; 6.7%, post-epidemic), with seasonal peaks from late summer to autumn during epidemic, and from fall to winter during post-epidemic period, which was highest in children aged 7-17 years. In epidemic, no statistical difference was found in the positive rates between children and adults among most months (except February, July and August), neither for the positive rates among age groups (P = 0.801). However, in post-epidemic period, significant differences were observed in the positive rates between children and adults in nearly every month (P<0.05 or P<0.001, except May), as well as in the positive rates among age groups (P<0.001). Most of the older patient admissions and all of ICU admissions occurred during the epidemic. Conclusions: Different patterns of age distribution and seasonality of M. pneumoniae RTIs between epidemic and post-epidemic periods were reported. Our results suggest that M. pneumoniae should be considered as a possible pathogen in pneumonia patients admitted to the ICU in the setting of an epidemic.
引用
收藏
页数:8
相关论文
共 39 条
[1]  
[Anonymous], EURO SURVEILL
[2]   A worldwide perspective of atypical pathogens in community-acquired pneumonia [J].
Arnold, Forest W. ;
Summersgill, James T. ;
Lajoie, Andrew S. ;
Peyrani, Paula ;
Marrie, Thomas J. ;
Rossi, Paolo ;
Blasi, Francesco ;
Fernandez, Patricia ;
File, Thomas M., Jr. ;
Rello, Jordi ;
Menendez, Rosario ;
Marzoratti, Lucia ;
Luna, Carlos M. ;
Ramirez, Julio A. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (10) :1086-1093
[3]   Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections [J].
Atkinson, Thomas Prescott ;
Balish, Mitchell F. ;
Waites, Ken B. .
FEMS MICROBIOLOGY REVIEWS, 2008, 32 (06) :956-973
[4]   PROTECTION OF IMMUNIZED AND PREVIOUSLY INFECTED CHIMPANZEES CHALLENGED WITH MYCOPLASMA-PNEUMONIAE [J].
BARILE, MF ;
GRABOWSKI, MW ;
KAPATAISZOUMBOIS, K ;
BROWN, B ;
HU, PC ;
CHANDLER, DKF .
VACCINE, 1994, 12 (08) :707-714
[5]   Mycoplasma pneumoniae Epidemiology in England and Wales: A National Perspective [J].
Brown, Rebecca J. ;
Nguipdop-Djomo, Patrick ;
Zhao, Hongxin ;
Stanford, Elaine ;
Spiller, O. Brad ;
Chalker, Victoria J. .
FRONTIERS IN MICROBIOLOGY, 2016, 7
[6]   High Prevalence of Macrolide Resistance in Mycoplasma pneumoniae Isolates from Adult and Adolescent Patients with Respiratory Tract Infection in China [J].
Cao, Bin ;
Zhao, Chun-Jiang ;
Yin, Yu-Dong ;
Zhao, Fei ;
Song, Shu-Fan ;
Bai, Lu ;
Zhang, Jian-Zhong ;
Liu, Ying-Mei ;
Zhang, Yu-Yu ;
Wang, Hui ;
Wang, Chen .
CLINICAL INFECTIOUS DISEASES, 2010, 51 (02) :189-194
[7]  
Chalker V., 2011, EURO SURVEILL, V16
[8]  
Chaudhry R, 2013, INDIAN J MED RES, V138, P244
[9]   Clonal Spread of a Unique Strain of Macrolide-Resistant Mycoplasma Pneumoniae Within a Single Family in Italy [J].
Chironna, Maria ;
Loconsole, Daniela ;
De Robertis, Anna Lisa ;
Morea, Anna ;
Scalini, Egidio ;
Quarto, Michele ;
Tafuri, Silvio ;
Germinario, Cinzia ;
Manzionna, Mariano .
MEDICINE, 2016, 95 (11)
[10]   Laboratory diagnosis of Mycoplasma pneumoniae infection [J].
Daxboeck, F ;
Krause, R ;
Wenisch, C .
CLINICAL MICROBIOLOGY AND INFECTION, 2003, 9 (04) :263-273