Exercise training accelerates the removal from plasma of LDL-like nanoemulsion in moderately hypercholesterolemic subjects

被引:8
作者
Ficker, Elisabeth S. [1 ]
Maranhao, Raul C. [1 ,2 ]
Chacra, Ana P. M. [1 ]
Neves, Vanessa C. [1 ]
Negrao, Carlos E. [1 ]
Martins, Vanessa C. N. [1 ]
Vinagre, Carmen G. C. de M. [1 ]
机构
[1] Univ Sao Paulo, Heart Inst InCor, Med Sch Hosp, Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
Exercise training; Hypercholesterolemia; Nanoparticles; Nanoemulsion; LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; CHOLESTEROL-RICH EMULSION; UNTRAINED SUBJECTS; BODY-FAT; MEN; KINETICS; MICROEMULSION; BEHAVIOR; PATHWAY;
D O I
10.1016/j.atherosclerosis.2010.04.030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Exercise training improves plasma lipid profile and diminishes risk of coronary heart disease. Previously, we showed that training increases LDL plasma clearance, as tested by an artificial LDL-like nanoemulsion method, presumably by increasing LDL receptor activity. In this study, we investigated whether training could also improve LDL clearance in hypercholesterolemic subjects (HCh) that are exposed to increased risk of cardiovascular events. Methods: Twenty sedentary HCh and 20 normolipidemic (NL) sedentary volunteers were divided into four groups: 12 HCh submitted to 4-month training program, 8 HCh with no exercise program, 12 NL submitted to 4-month training and 8 NL with no exercise program. An LDL-like nanoemulsion labeled with 14C-cholesteryl ester was injected intravenously into all subjects and plasma samples were collected during 24h after injection to determine the fractional clearance rate (FCR, in h-1) by compartmental analysis. The study was performed on the first and on the last day of the 4-month study period. Results: In both, trained HCh and NL groups, training increased nanoemulsion FCR by 36% (0.0443 +/- 0.0126; 0.0602 +/- 0.0187, p=0.0187 and 0.0503 +/- 0.0203; 0.0686 +/- 0.0216, p=0.0827, respectively). After training, LDL cholesterol diminished in both HCh and NL groups. In HCh, but not in NL group, LDL susceptibility to oxidation decreased, but oxidized LDL was unchanged. In both non-trained groups FCR was the same for the last and the 4-month previous evaluation. Conclusion: In HCh, exercise training increased the removal of LDL as tested by the nanoemulsion, and this probably accounted for decreased LDL cholesterol and diminished LDL susceptibility to oxidation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:230 / 236
页数:7
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