Controllers of the immune system and a new promise for immunotherapy

被引：158
作者：
Banchereau, J
Paczesny, S
Blanco, P
Bennett, L
Pascual, V
Fay, J
Palucka, AK
机构：
[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA
[2] Univ Texas, SW Med Ctr, Dallas, TX USA
来源：
IMMUNE MECHANISMS AND DISEASE | 2003年 / 987卷
关键词：
dendritic cells; Langerhans cells; interstitial DCs; T cells; immunotherapy;
D O I：
10.1111/j.1749-6632.2003.tb06047.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.
引用
收藏
页码：180 / 187
页数：8
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