Multiple sclerosis

被引:63
作者
Frohman, EM [1 ]
机构
[1] Univ Texas, SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75235 USA
关键词
D O I
10.1016/S0025-7125(03)00008-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Multiple sclerosis (MS) is the most common disabling neurologic disease of young people affecting between 350 and 450,000 individuals in the United States. Substantial advances have been made in the diagnostic assessment and treatment interventions over the last 10 years such that we are now able effectively to treat both the disease process and the associated symptomatic complaints associated with MS. Most patients consult with their primary care physician at the time when the first clinical manifestations of MS emerge. These physicians play a central role in the early identification and treatment of patients with MS. This article emphasizes the expanding diagnostic and therapeutic capabilities evolving for the MS patient and the crucial role played by primary care physicians in collaboration with neurologists in the coordination of the initial diagnostic and treatment plan.
引用
收藏
页码:867 / +
页数:33
相关论文
共 67 条
  • [1] Multiple sclerosis -: From probable to definite diagnosis -: A 7-year prospective study
    Achiron, A
    Barak, Y
    [J]. ARCHIVES OF NEUROLOGY, 2000, 57 (07) : 974 - 979
  • [2] REVISED ESTIMATE OF THE PREVALENCE OF MULTIPLE-SCLEROSIS IN THE UNITED-STATES
    ANDERSON, DW
    ELLENBERG, JH
    LEVENTHAL, CM
    REINGOLD, SC
    RODRIGUEZ, M
    SILBERBERG, DH
    [J]. ANNALS OF NEUROLOGY, 1992, 31 (03) : 333 - 336
  • [3] THE EFFECT OF CORTICOSTEROIDS FOR ACUTE OPTIC NEURITIS ON THE SUBSEQUENT DEVELOPMENT OF MULTIPLE-SCLEROSIS
    BECK, RW
    CLEARY, PA
    TROBE, JD
    KAUFMAN, DI
    KUPERSMITH, MJ
    PATY, DW
    BROWN, CH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (24) : 1764 - 1769
  • [4] A RANDOMIZED, CONTROLLED TRIAL OF CORTICOSTEROIDS IN THE TREATMENT OF ACUTE OPTIC NEURITIS
    BECK, RW
    CLEARY, PA
    ANDERSON, MM
    KELTNER, JL
    SHULTS, WT
    KAUFMAN, DI
    BUCKLEY, EG
    CORBETT, JJ
    KUPERSMITH, MJ
    MILLER, NR
    SAVINO, PJ
    GUY, JR
    TROBE, JD
    MCCRARY, JA
    SMITH, CH
    CHROUSOS, GA
    THOMPSON, HS
    KATZ, BJ
    BRODSKY, MC
    GOODWIN, JA
    ATWELL, CW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (09) : 581 - 588
  • [5] A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
    Brex, PA
    Ciccarelli, O
    O'Riordan, JI
    Sailer, M
    Thompson, AJ
    Miller, DH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (03) : 158 - 164
  • [6] Assessing the risk of early multiple sclerosis in patients with clinically isolated syndromes: the role of a follow up MRI
    Brex, PA
    Miszkiel, KA
    O'Riordan, JI
    Plant, GT
    Moseley, IF
    Thompson, AJ
    Miller, DH
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (03) : 390 - 393
  • [7] Multisequence MRI in clinically isolated syndromes and the early development of MS
    Brex, PA
    O'Riordan, JI
    Miszkiel, KA
    Moseley, IF
    Thompson, AJ
    Plant, GT
    Miller, DH
    [J]. NEUROLOGY, 1999, 53 (06) : 1184 - 1190
  • [8] Brodsky M, 1997, NEUROLOGY, V49, P1404
  • [9] THE ADHESION MOLECULE AND CYTOKINE PROFILE OF MULTIPLE-SCLEROSIS LESIONS
    CANNELLA, B
    RAINE, CS
    [J]. ANNALS OF NEUROLOGY, 1995, 37 (04) : 424 - 435
  • [10] Effect of early interferon treatment on conversion to definite multiple sclerosis:: a randomised study
    Comi, G
    Filippi, M
    Barkhof, F
    Durelli, L
    Edan, G
    Fernández, O
    Hartung, HP
    Seeldrayers, P
    Sorensen, PS
    Rovaris, M
    Martinelli, V
    Hommes, OR
    [J]. LANCET, 2001, 357 (9268) : 1576 - 1582