Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

被引:94
作者
Roohbakhsh, Ali [1 ]
Karimi, Gholamreza [1 ]
Iranshahi, Mehrdad [2 ]
机构
[1] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran
关键词
Lycopene; beta-Carotene; Astaxanthin; Nephropathy; Diabetes mellitus; Retinopathy; WHITE ADIPOSE-TISSUE; OXIDATIVE STRESS; SERUM CAROTENOIDS; BETA-CAROTENE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ALPHA-TOCOPHEROL; PLASMA-CONCENTRATIONS; CATARACT-EXTRACTION; MEMORY IMPAIRMENTS;
D O I
10.1016/j.biopha.2017.04.057
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Carotenoids are a large class of natural antioxidants that occur in many vegetables, foods and other natural sources. To date, a large number of biological properties have been reported from carotenoids, particularly protective effects against diabetes mellitus (DM), cancer, and neurodegenerative, metabolic and cardiovascular diseases. However, recent studies including clinical evidences, have shown that carotenoids play a role in the treatment of diabetes via enhancing insulin sensitivity. They are also able to protect the body from long-term consequences of diabetes including infectious diseases, nephropathy, neuronal and eye abnormalities. In this review, we try to discuss the mechanisms behind the biological effects of carotenoids for the prevention and treatment of DM and its complications. The authors believe that carotenoids will have a prominent place in the treatment of DM and its complications in the future. (C) 2017 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:31 / 42
页数:12
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