Laser therapy for the treatment of Hailey-Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing

被引:13
|
作者
Falto-Aizpurua, L. A. [1 ]
Griffith, R. D. [1 ]
Yazdani Abyaneh, M. A. [1 ]
Nouri, K. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA
关键词
BENIGN CHRONIC PEMPHIGUS; PHOTODYNAMIC THERAPY; DERMABRASION; CYCLOSPORINE; VAPORIZATION;
D O I
10.1111/jdv.12875
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Benign familial chronic pemphigus, or Hailey-Hailey disease (HHD), is a recurrent bullous dermatitis that tends to have a chronic course with frequent relapses. Long-term treatment options include surgery with skin grafting or dermabrasion. Both are highly invasive and carry significant risks and complications. More recently, laser-abrasion' has been described as a less invasive option with a better side-effect profile. In this article, we systematically review the safety and efficacy of carbon dioxide laser therapy as a long-term treatment option for HHD, as well as provide a review of other lasers that have been reported with this goal. A total of 23 patients who had been treated with a carbon dioxide laser were identified. After treatment, 10 patients (43%) had had no recurrence, 10 (43%) had greater than 50% improvement, 2 (8%) had less than 50% improvement and 1 (4%) patient had no improvement at all (follow-up period ranged from 4 to 144months). Laser parameter variability was wide and adverse effects were minimal, including dyspigmentation and scarring. Reviewed evidence indicates this therapy offers a safe, effective treatment alternative for HHD with minimal risk of side-effects. Larger, well-designed studies are necessary to determine the optimal treatment parameters.
引用
收藏
页码:1045 / 1052
页数:8
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