Immunohistochemical Findings of an Autopsied Lung Specimen from a Patient with Pandemic Influenza (A/H1N1pdm) Virus Infection

被引：2

作者：

Fujita, Jiro ^{[1
]}

Higa, Hajime ^{[2
]}

Azuma, Masato ^{[2
]}

Kin, Meika ^{[2
]}

Kakazu, Koichiro ^{[2
]}

Toume, Masahiko ^{[2
]}

Nakazato, Iwao ^{[3
]}

Cash, Haley L. ^{[1
]}

Higa, Futoshi ^{[1
]}

Tateyama, Masao ^{[1
]}

Tsutsumi, Yutaka ^{[4
]}

Ohtsuki, Yuji ^{[5
]}

机构：

[1] Univ Ryukyus, Fac Med, Dept Internal Med 1, Dept Infect Resp & Digest Med Control & Prevent I, Nishihara, Okinawa 90301, Japan

[2] Okinawa Prefectural Nanbu Med Ctr, Dept Internal Med, Okinawa, Japan

[3] Okinawa Prefectural Nanbu Med Ctr, Dept Pathol, Okinawa, Japan

[4] Fujita Hlth Univ, Dept Pathol, Sch Med, Toyoake, Aichi, Japan

[5] Matsuyama Shimin Hosp, Div Pathol, Matsuyama, Ehime, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 05期

关键词：

influenza virus; pneumonia; alveolar orifice; type II epithelial cells; smooth muscle cells; A H1N1; EXPRESSION; PNEUMONIA; CELLS;

D O I：

10.2169/internalmedicine.51.6197

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 24-year-old female presented with fever and dry cough. Influenza A virus infection was suspected and the patient was treated with neuraminidase inhibitors. Five days after diagnosis, the patient developed persistent fever and dyspnea, and was diagnosed with severe pneumonia. Despite intensive treatment, the pneumonia worsened and the patient died 14 days after admission. At autopsy, a diffuse alveolar damage ( DAD) pattern was observed. Immunohistochemical evaluation indicated severe epithelial damage, resulting in successive regeneration of alveolar type II cells followed by marked proliferation of smooth muscle cells and an increase of collagen fibers at the tip of alveolar orifices.

引用

页码：507 / 512

页数：6

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