Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: A mechanistic study

被引：82

作者：

Veerapur, V. P. ^{[1
,2
]}

Prabhakar, K. R. ^{[2
]}

Thippeswamy, B. S. ^{[1
]}

Bansal, Punit ^{[2
]}

Srinivasan, K. K. ^{[2
]}

Unnikrishnan, M. K. ^{[2
]}

机构：

[1] Sree Siddaganga Coll Pharm, Tumkur 572102, Karnataka, India

[2] Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India

来源：

FOOD CHEMISTRY | 2012年 / 132卷 / 01期

关键词：

Ficus racemosa; High-fat diet-fed; STZ; DPP-IV; PPAR-gamma; PTB-1B; Glucose uptake; Bergenin; DIPEPTIDYL PEPTIDASE-IV; INSULIN-RESISTANCE; INHIBITORS; MELLITUS; EXTRACT; GAMMA; PARTS;

D O I：

10.1016/j.foodchem.2011.10.052

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present study was designed to investigate the effects of the ethanol extract of Ficus racemosa (FRE) on biochemical parameters in type 2-like diabetes, induced by a combination of standardised high-fat diet and low-dose streptozotocin (25 mg kg(-1), i.p.) in rats. To elucidate the mode of action of FRE, its effects on a battery of targets involved in glucose homeostasis was evaluated. FRE (200 and 400 mg kg(-1), p.o.), in a dose-dependent manner, altered the biochemical parameters and significantly improved glucose tolerance and HDL-c levels. In different bioassays, FRE showed inhibition of PTP-1B (IC50 12.1 mu g/mL) and DPP-IV (42.5%). FRE exhibited 82.6% binding to PPAR-gamma. Furthermore FRE exhibited stimulation of glucose uptake by skeletal muscles (hemi-diaphragm). Bergenin was quantified in bioactive-FRE by high-performance liquid chromatography (0.15% w/w). This is the first report demonstrating the effectiveness of F. racemosa stem bark in type 2 diabetes and targets involved in it. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：186 / 193

页数：8

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