New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

被引：15

作者：

Hien Minh Nguyen ^{[1
]}

Ito, Takuya ^{[1
]}

Nwet Nwet Win ^{[1
,3
]}

Kodama, Takeshi ^{[1
]}

Vo Quoc Hung ^{[2
]}

Hoai Thi Nguyen ^{[2
]}

Morita, Hiroyuki ^{[1
]}

机构：

[1] Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan

[2] Hue Univ Med & Pharm, Fac Pharm, 06 Ngo Quyen, Hue, Vietnam

[3] Univ Yangon, Dept Chem, Yangon 11041, Myanmar

来源：

PHYTOCHEMISTRY LETTERS | 2016年 / 17卷

关键词：

Marine sponge; Spongia sp; Sesquiterpene aminoquinone; 4,9-Friedodrimane; Antibacterial activities; Smenospongine; SMENOSPONGIA SP; QUINONES; HYDROQUINONE; AVAROL; CELLS;

D O I：

10.1016/j.phytol.2016.08.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3-9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1-9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

引用

页码：288 / 292

页数：5

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