Propofol-induced hallucinations and dreams

被引：6

作者：

Marchaisseau, Virginie ^{[1
]}

Molia, Aurelie ^{[1
]}

Herlem, Emmanuelle ^{[1
]}

Germain, Marie-Laure ^{[1
]}

Trenque, Thierry ^{[1
]}

机构：

[1] Ctr Hosp Univ, Ctr Reg Pharmacovigilance Reims Champagne Ardenne, F-51092 Reims, France

来源：

THERAPIE | 2008年 / 63卷 / 02期

关键词：

propofol; hallucinations; dreams;

D O I：

10.2515/therapie:2008036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Through a review of both the cases in the national pharmacovigilance database and the literature, we evaluated the importance of propofol-induced hallucinations and dreams which are not mentioned in the propofol Summaries of Product Characteristics (SPC). Postoperative hallucinations occurring in patients anaesthetized by propofol is not exceptional even with low doses of propofol. Most of the hallucinations are described as pleasant with a frequent "sexual connotation", uninhibited behavior or a verbal expression of patient's intimate thoughts. In the same way, many studies about anaesthetics highlight the supporting role of propofol in the occurrence of pleasant dreams. Finally these effects should be mentioned in the propofol SPC due to the legal implication they might lead to.

引用

页码：141 / 144

页数：4

共 19 条

[1]

BEGAUD B, 1985, THERAPIE, V40, P111

[2] Convulsions, ataxia and hallucinations following propofol [J].

Bendiksen, A ;

Larsen, LM .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1998, 42 (06) :739-741

[3] Dreams, images and emotions associated with propofol anaesthesia [J].

Brandner, B ;

Blagrove, M ;

McCallum, G ;

Bromley, LM .

ANAESTHESIA, 1997, 52 (08) :750-755

[4]

BRICKER SRW, 1988, ANAESTHESIA, V43, P171

[5] Recollection of dreams after short general anaesthesia: influence on patient anxiety and satisfaction [J].

Hellwagner, K ;

Holzer, A ;

Gustorff, B ;

Schroegendorfer, K ;

Greher, M ;

Weindlmayr-Goettel, M ;

Saletu, B ;

Lackner, FX .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2003, 20 (04) :282-288

[6] AROUSAL FROM PROPOFOL [J].

HUNTER, DN ;

THORNILY, A ;

WHITBURN, R .

ANAESTHESIA, 1987, 42 (10) :1128-1129

[7] Incidence and quality of dreaming during anaesthesia with propofol in comparison with enflurance [J].

Kasmacher, H ;

Petermeyer, M ;

Decker, C .

ANAESTHESIST, 1996, 45 (02) :146-153

[8] SEXUAL ILLUSIONS AND PROPOFOL SEDATION [J].

KENT, EA ;

BACON, DR ;

HARRISON, P ;

LEMA, MJ .

ANESTHESIOLOGY, 1992, 77 (05) :1037-1038

[9] 4D-QSAR analysis of a set of propofol analogues:: Mapping binding sites for an anesthetic phenol on the GABAA receptor [J].

Krasowski, MD ;

Hong, XA ;

Hopfinger, AJ ;

Harrison, NL .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (15) :3210-3221

[10] Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type a receptor distinct from that for isoflurane [J].

Krasowski, MD ;

Koltchine, VV ;

Rick, CE ;

Ye, Q ;

Finn, SE ;

Harrison, NL .

MOLECULAR PHARMACOLOGY, 1998, 53 (03) :530-538

← 1 2 →