Relay Rh(II)/Pd(0) Dual Catalysis: Selective Construction of Cyclic All-Quaternary Carbon Centers

被引：32
作者：
Chen, Zi-Sheng [1 ]
Huang, Xiao-Yan [1 ]
Gao, Jin-Ming [1 ]
Ji, Kegong [1 ]
机构：
[1] Northwest A&F Univ, Coll Sci, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 22期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; ASYMMETRIC ALLYLIC ALKYLATION; ALPHA-DIAZOCARBONYL COMPOUNDS; ORGANIC-SYNTHESIS; REACTIONS (MC)R-2; MULTICATALYTIC REACTIONS; SYNTHETIC STRATEGY; DIAZO-COMPOUNDS; BETA-LACTONES; INSERTION;
D O I：
10.1021/acs.orglett.6b02958
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel relay Rh(II)/Pd(0) dual catalysis strategy that promotes the divergent reaction of a-diazo-carbonyl compounds with allylic carboxylates for the selective construction of cyclic all-quaternary carbon centers has been developed. This binary catalyst system rendered domino C-H insertion/allylic alkylation process under mild conditions. Remarkably, the domino catalytic reaction shows good selectivity and excellent tolerance to various functionalities and is operationally simple.
引用
收藏
页码：5876 / 5879
页数：4
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