Radon epidemiology and nuclear track detectors: Methods, results and perspectives

An important achievement of nuclear track detectors is that they render it possible to measure a large number of radon concentrations. These are necessary for epidemiological studies aimed to estimate the lung cancer risk due to exposure to radon and its decay products in dwellings. Many case-control studies were conducted in the last 15 years in Europe, North America and China, in order to avoid the uncertainties associated with the risk extrapolation from epidemiological studies on miners exposed in underground mines. In this review paper, the main methodological issues of these studies are introduced: confounding factors, the impact of radon exposure uncertainties on the estimated risk, the retrospective assessment of radon exposure through the measurement of Po-210 surface concentration on glass objects, the interaction between radon and smoking, statistical methods to analyze data and combine studies, etc. As regards the estimated risk of lung cancer, the main characteristics and results of each study are reported and discussed, together with the results of meta-analyses and, most importantly, of the three recently published analyses that pool 2 Chinese, 7 North American, and 13 European studies. Finally, some conclusions are given and a brief reference is made to ongoing studies. (c) 2005 Elsevier Ltd. All rights reserved.