Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils

被引：25

作者：

Eisenberg, David S. ^{[1
,2
,3
]}

Sawaya, Michael R. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, UCLA DOE Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2016年 / 113卷 / 34期

关键词：

BETA-AMYLOID FIBRILS; POLYMORPHISM; PLAQUES; PROTEIN;

D O I：

10.1073/pnas.1610806113

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：9398 / 9400

页数：3

共 16 条

[1] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[2] Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism [J].

Cohen, Samuel I. A. ;

Linse, Sara ;

Luheshi, Leila M. ;

Hellstrand, Erik ;

White, Duncan A. ;

Rajah, Luke ;

Otzen, Daniel E. ;

Vendruscolo, Michele ;

Dobson, Christopher M. ;

Knowles, Tuomas P. J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (24) :9758-9763

[3] Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils [J].

Colvin, Michael T. ;

Silvers, Robert ;

Ni, Qing Zhe ;

Can, Thach V. ;

Sergeyev, Ivan ;

Rosay, Melanie ;

Donovan, Kevin J. ;

Michael, Brian ;

Wall, Joseph ;

Linse, Sara ;

Griffin, Robert G. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (30) :9663-9674

[4] THE CARBOXY TERMINUS OF THE BETA-AMYLOID PROTEIN IS CRITICAL FOR THE SEEDING OF AMYLOID FORMATION - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMERS-DISEASE [J].

JARRETT, JT ;

BERGER, EP ;

LANSBURY, PT .

BIOCHEMISTRY, 1993, 32 (18) :4693-4697

[5] Pathogenic Protein Seeding in Alzheimer Disease and Other Neurodegenerative Disorders [J].

Jucker, Mathias ;

Walker, Lary C. .

ANNALS OF NEUROLOGY, 2011, 70 (04) :532-540

[6] CLINICAL, PATHOLOGICAL, AND NEUROCHEMICAL CHANGES IN DEMENTIA - A SUBGROUP WITH PRESERVED MENTAL STATUS AND NUMEROUS NEOCORTICAL PLAQUES [J].

KATZMAN, R ;

TERRY, R ;

DETERESA, R ;

BROWN, T ;

DAVIES, P ;

FULD, P ;

XIONG, RB ;

PECK, A .

ANNALS OF NEUROLOGY, 1988, 23 (02) :138-144

[7] The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model [J].

Li, Tong ;

Braunstein, Kerstin E. ;

Zhang, Juhong ;

Lau, Ashley ;

Sibener, Leslie ;

Deeble, Christopher ;

Wong, Philip C. .

NATURE COMMUNICATIONS, 2016, 7

[8] Structure of the cross-β spine of amyloid-like fibrils [J].

Nelson, R ;

Sawaya, MR ;

Balbirnie, M ;

Madsen, AO ;

Riekel, C ;

Grothe, R ;

Eisenberg, D .

NATURE, 2005, 435 (7043) :773-778

[9] Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils [J].

Paravastu, Anant K. ;

Leapman, Richard D. ;

Yau, Wai-Ming ;

Tycko, Robert .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (47) :18349-18354

[10] Self-propagating, molecular-level polymorphism in Alzheimer's β-amyloid fibrils [J].

Petkova, AT ;

Leapman, RD ;

Guo, ZH ;

Yau, WM ;

Mattson, MP ;

Tycko, R .

SCIENCE, 2005, 307 (5707) :262-265

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