Mycophenolate mofetil in pediatric renal transplantation

被引：34
作者：
Ettenger, R
Sarwal, MM
机构：
[1] Univ Calif Los Angeles, Med Ctr, Mattel Childrens Hosp, Los Angeles, CA 90095 USA
[2] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA
来源：
TRANSPLANTATION | 2005年 / 80卷 / 02期
关键词：
mycophenolate mofetil; mycophenolic acid; pediatrics; renal transplantation; therapeutic drug monitoring;
D O I：
10.1097/01.tp.0000186957.32801.c0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycophenolate mofetil (MMF) has become a popular immunosuppressive agent in pediatric renal transplantation and has helped to address the unique challenges of transplantation in this population. This paper reviews the early Studies that proved MMF's efficacy in reducing the risk of acute renal rejection, as well as its safety and tolerability in comparison to azathioprine. Key conclusions about the pharmacokinetics of MMF from studies of MMF a lone and in combination with other immunosuppressive therapies are Outlined. The importance of therapeutic drug Monitoring (TDM) in this Population is also explored in this review. Finally, recent studies showing that newer agents used in combination with MMF can further increase efficacy and reduce the risk of adverse events such as posttransplant lymphoproliferative disease are discussed.
引用
收藏
页码：S201 / S210
页数：10
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