Copper-/Silver-Mediated Arylation of C(sp2)-H Bonds with 2-Thiophenecarboxylic Acids

被引：66

作者：

Zhao, Sheng ^{[1
]}

Liu, Yue-Jin ^{[1
]}

Yan, Sheng-Yi ^{[1
]}

Chen, Fa-Jie ^{[1
]}

Zhang, Zhuo-Zhuo ^{[1
]}

Shi, Bing-Feng ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 13期

关键词：

C-H BONDS; CATALYZED DECARBOXYLATIVE ARYLATION; CARBOXYLIC-ACIDS; UNACTIVATED C(SP(3))-H; ORTHO-HALOGENATION; COUPLING REACTIONS; BENZOIC-ACIDS; PALLADIUM; ARENES; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.5b01560

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved.

引用

页码：3338 / 3341

页数：4

共 69 条

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