Conformational analysis of meropenem and desmethyl meropenem: The effect of 1 beta-methyl group on carbapenem antibiotics

被引：4

作者：

Igarashi, J ^{[1
]}

Nishimura, T ^{[1
]}

Sasaki, A ^{[1
]}

Sunagawa, M ^{[1
]}

机构：

[1] SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA KU,OSAKA 554,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00341-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and H-1 NMR experiments. It was found that the preferred conformation of meropenem was relatively Linear compared with desmethyl meropenem in aqueous solution. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1881 / 1886

页数：6

共 35 条

[21] CONFORMATIONAL-ANALYSIS OF CYTIDINE, "1-BETA-D-(ARABINOFURANOSYL)CYTOSINE AND THEIR O'-METHYL DERIVATIVES BY PROTON MAGNETIC-RESONANCE SPECTROSCOPY
REMIN, M
SHUGAR, D
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (24) : 8146 - 8156
[22] PHARMACOKINETICS AND SAFETY OF BO-2727, A NEW INJECTABLE 1-BETA-METHYL CARBAPENEM ANTIBIOTIC, AND ITS EFFECT ON THE FECAL MICROFLORA IN HEALTHY MALE-VOLUNTEERS
NAKASHIMA, M
UEMATSU, T
KOSUGE, K
NAKAGAWA, S
HATA, S
SANADA, M
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 33 (05) : 987 - 998
[23] CONFORMATIONAL-ANALYSIS OF AMINO-ACIDS AND PEPTIDES USING SPECIFIC ISOTOPE SUBSTITUTION .2. CONFORMATION OF SERINE, TYROSINE, PHENYLALANINE, ASPARTIC-ACID, ASPARAGINE, AND ASPARTIC-ACID BETA-METHYL ESTER IN VARIOUS IONIZATION STATES
KAINOSHO, M
AJISAKA, K
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (19) : 5630 - 5631
[24] EFFECT OF REPLACING 1 OF HYDROGENS OF BETA-CARBON OF BETA-MERCAPTOPROPIONIC ACID RESIDUE IN DEAMINO-OXYTOCIN BY A METHYL GROUP ON ITS OXYTOCIC AND AVIAN VASODEPRESSOR ACTIVITY
SCHULZ, H
DUVIGNEA.V
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (21) : 5015 - &
[25] Effect of side chains including the N-methyl-tetrazole-thiol group of β-lactam antibiotics on transport in cultured kidney epithelial cells LLC-PK1
Goto, K
Oda, M
Saitoh, H
Nishida, M
Takada, M
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (10) : 1113 - 1116
[26] Shielding effect of carbonyl group and its application to the conformational analysis of 1,1,10,10-tetramethyl[3.3]metacyclophane-2,11-dione
Fukazawa, Y
Yang, YY
Hayashibara, T
Usui, SJ
TETRAHEDRON, 1996, 52 (08) : 2847 - 2862
[27] THE FIXING ROLE OF THE TERT-BUTYL GROUP IN THE CONFORMATIONAL PROPERTIES OF ACYCLIC SULFUR-COMPOUNDS - SYNTHESIS AND CONFORMATIONAL-ANALYSIS OF 2-TERT-BUTYLTHIODERIVATIVES OF 1-PHENYLETHANOL AND THEIR O-METHYL ANALOGS
FERNANDEZ, I
LLERA, JM
ZORRILLA, F
ALCUDIA, F
TETRAHEDRON, 1989, 45 (09) : 2703 - 2718
[28] Effect of 7 beta-methyl substituent on human type1/type2 5 alpha-reductase inhibition/selectivity in 17 beta-substituted 4-aza-5 alpha-androstan-3-one steroids: Synthesis and biological activity.
Bakshi, RK
Rasmusson, GH
Patel, GF
Tolman, RL
Chang, B
Ellsworth, K
Harris, GS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 59 - MEDI
[29] Shielding Effect of Carbonyl Group and its Application to the Conformational Analysis of 1,1,10,10-Tetramethyl[3. 3]metacyclophane-2,11-dione
Fukazawa, Y.
Yang, Y.
Hayashibara, T.
Usui, S.
Tetrahedron, 52 (08):
[30] SELECTIVE AND POTENT BETA-2-ADRENOCEPTOR AGENTS WITHIN THE TETRAHYDROISOQUINOLINE CLASS - EFFECT OF METHYL SUBSTITUTION AT THE BENZYLIC CARBON OF THE 1-(3,4,5-TRIMETHOXYBENZYL) GROUP OF TRIMETOQUINOL
SOBER, DJ
CHANG, J
FOWBLE, JW
MUKHOPADHYAY, A
FELLER, DR
MILLER, DD
FAIRCHILD, EH
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (08) : 970 - 974

← 1 2 3 4 →