Conformational analysis of meropenem and desmethyl meropenem: The effect of 1 beta-methyl group on carbapenem antibiotics

被引：4
|
作者：
Igarashi, J [1 ]
Nishimura, T [1 ]
Sasaki, A [1 ]
Sunagawa, M [1 ]
机构：
[1] SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA KU,OSAKA 554,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期
关键词：
D O I：
10.1016/0960-894X(96)00341-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and H-1 NMR experiments. It was found that the preferred conformation of meropenem was relatively Linear compared with desmethyl meropenem in aqueous solution. Copyright (C) 1996 Elsevier Science Ltd
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页码：1881 / 1886
页数：6
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