No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

被引：27
|
作者：
Petrill, SA
Plomin, R
McClearn, GE
Smith, DL
Vignetti, S
Chorney, MJ
Chorney, K
Thompson, LA
Detterman, DK
Benbow, C
Lubinski, D
Daniels, J
Owen, M
McGuffin, P
机构：
[1] INST PSYCHIAT, LONDON, ENGLAND
[2] PENN STATE UNIV, MILTON S HERSHEY MED CTR, UNIVERSITY PK, PA 16802 USA
[3] CASE WESTERN RESERVE UNIV, CLEVELAND, OH 44106 USA
[4] IOWA STATE UNIV, AMES, IA 50011 USA
[5] UNIV WALES COLL MED, CARDIFF CF4 4XN, S GLAM, WALES
来源：
BEHAVIOR GENETICS | 1997年 / 27卷 / 01期
关键词：
intelligence; D2 dopamine receptor; spatial ability; quantitative trait loci; association; DNA MARKERS; LOW IQ; PROJECT;
D O I：
10.1023/A:1025659124405
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.
引用
收藏
页码：29 / 31
页数：3
相关论文
共 50 条
  • [41] D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics
    Antolin, Tim
    Berman, Steven M.
    Conner, Bradley T.
    Ozkaragoz, Tulin Z.
    Sheen, Courtney L.
    Ritchie, Terry L.
    Noble, Ernest P.
    PSYCHIATRY RESEARCH, 2009, 166 (2-3) : 91 - 101
  • [42] D2 dopamine receptor gene (DRD2) Taq1A (rs1800497) affects bone density
    Chiang, Ting-, I
    Lane, Hsien-Yuan
    Lin, Chieh-Hsin
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [43] Low methylation rates of dopamine receptor D2 gene promoter sites in Japanese schizophrenia subjects
    Yoshino, Yuta
    Kawabe, Kentaro
    Mori, Takaaki
    Mori, Yoko
    Yamazaki, Kiyohiro
    Numata, Shusuke
    Nakata, Shunsuke
    Yoshida, Taku
    Iga, Jun-ichi
    Ohmori, Tetsuro
    Ueno, Shu-ichi
    WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2016, 17 (06) : 449 - 456
  • [44] The Taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity
    Southon, A
    Walder, K
    Sanigorski, AM
    Zimmet, P
    Nicholson, GC
    Kotowicz, MA
    Collier, G
    DIABETES NUTRITION & METABOLISM, 2003, 16 (01) : 72 - 76
  • [45] TaqIA polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patients
    Winkler, Julia K.
    Woehning, Annika
    Schultz, Jobst-Hendrik
    Brune, Maik
    Beaton, Nigel
    Challa, Tenagne Delessa
    Minkova, Stella
    Roeder, Eva
    Nawroth, Peter P.
    Friederich, Hans-Christoph
    Wolfrum, Christian
    Rudofsky, Gottfried
    NUTRITION, 2012, 28 (10) : 996 - 1001
  • [46] Association study of 12 polymorphisms spanning the dopamine D2 receptor gene and clozapine treatment response in two treatment refractory/intolerant populations
    Rudi Hwang
    Takahiro Shinkai
    Vincenzo De Luca
    Daniel J. Müller
    Xingqun Ni
    Fabio Macciardi
    Steven Potkin
    Jeffrey A. Lieberman
    Herbert Y. Meltzer
    James L. Kennedy
    Psychopharmacology, 2005, 181 : 179 - 187
  • [47] Association study of 12 polymorphisms spanning the dopamine D2 receptor gene and clozapine treatment response in two treatment refractory/intolerant populations
    Hwang, R
    Shinkai, T
    De Luca, V
    Müller, DJ
    Ni, XQ
    Macciardi, F
    Potkin, S
    Lieberman, JA
    Meltzer, HY
    Kennedy, JL
    PSYCHOPHARMACOLOGY, 2005, 181 (01) : 179 - 187
  • [48] The Association between Infections and General Cognitive Ability in Young Men - A Nationwide Study
    Benros, Michael Eriksen
    Sorensen, Holger Jelling
    Nielsen, Philip Rising
    Nordentoft, Merete
    Mortensen, Preben Bo
    Petersen, Liselotte
    PLOS ONE, 2015, 10 (05):
  • [49] The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients
    Xing, Qinghe
    Qian, Xueqing
    Li, Huafang
    Wong, Shiming
    Wu, Shengnan
    Feng, Guoyin
    Duan, Shiwei
    Xu, Mingqing
    Gao, Rui
    Qin, Wei
    Gao, Jianjun
    Meng, Junwei
    He, Lin
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2007, 10 (05) : 631 - 637
  • [50] Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients
    Zai, C. C.
    De Luca, V.
    Hwang, R. W.
    Voineskos, A.
    Mueller, D. J.
    Remington, G.
    Kennedy, J. L.
    MOLECULAR PSYCHIATRY, 2007, 12 (09) : 794 - 795
12345