The sterile controversy on the amyloid cascade hypothesis

被引:9
作者
Canevelli, Marco [1 ]
Bruno, Giuseppe [1 ]
Cesari, Matteo [2 ,3 ]
机构
[1] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy
[2] CHU Toulouse, Gerontopole, Toulouse, France
[3] Univ Toulouse III Paul Sabader, Toulouse, France
关键词
Alzheimer's disease; Amyloid; Randomized controlled trials; Aging; Biomarkers;
D O I
10.1016/j.neubiorev.2017.09.015
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In these last years, several phase III randomized controlled trials testing promising candidates sharing A beta) depots as target of their action have failed, despite showing some reductions of the brain A beta charge. The announcements of the negative results have heated the discussion in the field and divided the scientific community between the defenders versus the opponents of the A beta) theory. In the present article, we discuss the limits of these drastic, opposite positions and we propose a novel approach to Alzheimer's disease (AD). In particular, a "one fits -all" approach where a single biomarker/process is able to explain the clinical manifestation seems inadequate for AD (as for other conditions of old age). Accordingly, there is an urgent need to overcome the traditional paradigms of "standalone-diseases" (requiring unimodal interventions) in favor of more comprehensive and multidimensional approaches. Specifically, promoting biomarker modeling procedures based on multivariate statistical methodologies may have important implications and advantages in the field of AD and other neurodegenerative diseases.
引用
收藏
页码:472 / 473
页数:2
相关论文
共 6 条
[1]   Leading Alzheimer's theory survives drug failure [J].
Abbott, Alison ;
Dolgin, Elie .
NATURE, 2016, 540 (7631) :15-16
[2]   Solanezumab: too late in mild Alzheimer's disease? [J].
不详 .
LANCET NEUROLOGY, 2017, 16 (02) :97-97
[3]  
Calvani R., 2017, CURR PROTEIN PEPT SC
[4]   Systemic inflammation, body composition, and physical performance in old community-dwellers [J].
Calvani, Riccardo ;
Marini, Federico ;
Cesari, Matteo ;
Buford, Thomas W. ;
Manini, Todd M. ;
Pahor, Marco ;
Leeuwenburgh, Christiaan ;
Bernabei, Roberto ;
Landi, Francesco ;
Marzetti, Emanuele .
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2017, 8 (01) :69-77
[5]   The case for rejecting the amyloid cascade hypothesis [J].
Herrup, Karl .
NATURE NEUROSCIENCE, 2015, 18 (06) :794-799
[6]  
Mullard A, 2016, NAT REV DRUG DISCOV, V15, P3, DOI [10.1038/nrd.2016.281, 10.1038/nrd.2015.38]