Warburg Effect and Redox Balance

被引:121
作者
Hamanaka, Robert B. [1 ]
Chandel, Navdeep S. [1 ,2 ,3 ]
机构
[1] Northwestern Univ, Sch Med, Dept Med, Div Pulm & Crit Care, Chicago, IL 60611 USA
[2] Northwestern Univ, Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
[3] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA
关键词
PYRUVATE-KINASE M2; CELLS; PKM2; METABOLISM;
D O I
10.1126/science.1215637
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1219 / 1220
页数:2
相关论文
共 15 条
[1]   Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses [J].
Anastasiou, Dimitrios ;
Poulogiannis, George ;
Asara, John M. ;
Boxer, Matthew B. ;
Jiang, Jian-kang ;
Shen, Min ;
Bellinger, Gary ;
Sasaki, Atsuo T. ;
Locasale, Jason W. ;
Auld, Douglas S. ;
Thomas, Craig J. ;
Vander Heiden, Matthew G. ;
Cantley, Lewis C. .
SCIENCE, 2011, 334 (6060) :1278-1283
[2]  
Bluemlein K, 2011, ONCOTARGET, V2, P393
[3]   Regulation of cancer cell metabolism [J].
Cairns, Rob A. ;
Harris, Isaac S. ;
Mak, Tak W. .
NATURE REVIEWS CANCER, 2011, 11 (02) :85-95
[4]   The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].
Christofk, Heather R. ;
Vander Heiden, Matthew G. ;
Harris, Marian H. ;
Ramanathan, Arvind ;
Gerszten, Robert E. ;
Wei, Ru ;
Fleming, Mark D. ;
Schreiber, Stuart L. ;
Cantley, Lewis C. .
NATURE, 2008, 452 (7184) :230-U74
[5]   Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells [J].
Gruening, Nana-Maria ;
Rinnerthaler, Mark ;
Bluemlein, Katharina ;
Muelleder, Michael ;
Wamelink, Mirjam M. C. ;
Lehrach, Hans ;
Jakobs, Cornelis ;
Breitenbach, Michael ;
Ralser, Markus .
CELL METABOLISM, 2011, 14 (03) :415-427
[6]   Mitochondrial reactive oxygen species regulate hypoxic signaling [J].
Hamanaka, Robert B. ;
Chandel, Navdeep S. .
CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (06) :894-899
[7]   Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation [J].
Heiden, Matthew G. Vander ;
Cantley, Lewis C. ;
Thompson, Craig B. .
SCIENCE, 2009, 324 (5930) :1029-1033
[8]   Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth [J].
Hitosugi, Taro ;
Kang, Sumin ;
Heiden, Matthew G. Vander ;
Chung, Tae-Wook ;
Elf, Shannon ;
Lythgoe, Katherine ;
Dong, Shaozhong ;
Lonial, Sagar ;
Wang, Xu ;
Chen, Georgia Z. ;
Xie, Jianxin ;
Gu, Ting-Lei ;
Polakiewicz, Roberto D. ;
Roesel, Johannes L. ;
Boggon, Titus J. ;
Khuri, Fadlo R. ;
Gilliland, D. Gary ;
Cantley, Lewis C. ;
Kaufman, Jonathan ;
Chen, Jing .
SCIENCE SIGNALING, 2009, 2 (97) :ra73
[9]   Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription [J].
Lee, Jungwoon ;
Kim, Hye Kyoung ;
Han, Yong-Mahn ;
Kim, Jungho .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (05) :1043-1054
[10]   Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 [J].
Luo, Weibo ;
Hu, Hongxia ;
Chang, Ryan ;
Zhong, Jun ;
Knabel, Matthew ;
O'Meally, Robert ;
Cole, Robert N. ;
Pandey, Akhilesh ;
Semenza, Gregg L. .
CELL, 2011, 145 (05) :732-744