Sofosbuvir-Based Regimens in HIV/HCV Coinfected Patients After Liver Transplantation: Results From the ANRS CO23 CUPILT Study

被引:12
|
作者
Antonini, Teresa Maria [1 ,2 ,3 ,4 ]
Coilly, Audrey [1 ,2 ,3 ,4 ]
Rossignol, Emilie [5 ,6 ]
Fougerou-Leurent, Claire [5 ,6 ]
Dumortier, Jerome [7 ,8 ]
Leroy, Vincent [9 ,10 ]
Veislinger, Aurelie [5 ,6 ]
Radenne, Sylvie [11 ]
Botta-Fridlund, Danielle [12 ]
Durand, Francois [13 ]
Houssel-Debry, Pauline [14 ]
Kamar, Nassim [15 ,16 ,17 ]
Canva, Valerie [18 ]
Perre, Philippe [19 ]
De Ledinghen, Victor [20 ]
Rohel, Alexandra [21 ]
Diallo, Alpha [21 ]
Taburet, Anne-Marie [4 ,22 ,23 ]
Samuel, Didier [1 ,2 ,3 ,4 ]
Pageaux, Georges-Philippe [24 ,25 ]
Duclos-Vallee, Jean-Charles [1 ,2 ,3 ,4 ]
机构
[1] Hop Paul Brousse, AP HP, Ctr Hepato Biliaire, Villejuif, France
[2] Univ Paris Sud, Villejuif, France
[3] INSERM, Unite 1193, Villejuif, France
[4] DHU Hepatinov, Villejuif, France
[5] Rennes 1 Univ, Pontchaillou Univ Hosp, Serv Pharmacol, Rennes, France
[6] INSERM, CIC 1414, Rennes, France
[7] Hop Edouard Herriot Hepat, Unite Transplantat, Lyon, France
[8] Univ Claude Bernard Lyon 1, Lyon, France
[9] CHU Grenoble, Clin Univ Hepato Gastroenterol, Pole Digidune, Grenoble, France
[10] Univ Grenoble Alpes, U823, IAPC Inst Albert Bonniot, Unite INSERM, Grenoble, France
[11] Hop Croix Rousse, Serv Transplantat Hepat, Lyon, France
[12] CHU Concept, Serv Hepato Gastroenterol, Marseille, France
[13] Univ Paris VII, Hop Beaujon, INSERM U773, Serv Hepatol & Reanimat Hepatodigest, Clichy, France
[14] Univ Rennes 1, INSERM, Serv Malad Foie, U991, Rennes, France
[15] CHU Rangueil, Dept Organ Transplantat, Toulouse, France
[16] CHU Rangueil, INSERM, U1043, Toulouse, France
[17] Univ Paul Sabatier, IFR BMT, Toulouse, France
[18] CHRU Lille, Hop Huriez, Serv Hepatol, Lille, France
[19] CHD Vendee, Serv MPU Infectiol, La Roche Sur Yon, France
[20] CHU Bordeaux, Hop Haut Leveque, Serv Hepato Gastroenterol, Bordeaux, France
[21] ANRS France Rech Nord & Sud Sida HIV Hepatites, Unit Basic & Clin Res Viral Hepatitis, Paris, France
[22] Hop Bicetre, AP HP, HUPS, Pharmacie Clin, Le Kremlin Bicetre, France
[23] Univ Paris Sud, CEA, INSERM, UMR 1184, Le Kremlin Bicetre, France
[24] CHU St Eloi, Dept Hepatogastroenterol & Transplantat Hepat, Montpellier, France
[25] Univ Montpellier I, Montpellier, France
关键词
HEPATITIS-C VIRUS; FIBROSING CHOLESTATIC HEPATITIS; HUMAN-IMMUNODEFICIENCY-VIRUS; DACLATASVIR PLUS SOFOSBUVIR; HIV-INFECTED PATIENTS; HCV INFECTION; OPEN-LABEL; RIBAVIRIN; THERAPY; RECURRENCE;
D O I
10.1097/TP.0000000000001928
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. A recurrence of hepatitis C virus (HCV) after liver transplantation affects survival in human immunodeficiency virus (HIV)/HCV coinfected patients. This study assessed the efficacy and safety of sofosbuvir (SOF)-based regimens in HIV/HCV coinfected patients after liver transplantation. Methods. Twenty-nine HIV/HCV coinfected transplanted patients receiving tacrolimus-, cyclosporine-, or everolimus-based immunosuppressive therapy were enrolled in the Compassionate Use of Protease Inhibitors in Viral C Liver Transplantation cohort. Their antiviral treatment combined SOF, daclatasvir with or without ribavirin (n = 10/n = 6), or SOF, ledipasvir with or without ribavirin (n = 2/n = 11). Results. The median delay between liver transplantation and treatment initiation was 37.5 months (interquartile range [IQR], 14.4-99.2). The breakdown of HCV genotypes was G1, 22 patients (75.9%); G3, 3 patients (10.3%); and G4, 4 patients (13.8%). The treatment indications were HCV recurrence (>= F1 n = 23) or fibrosing cholestatic hepatitis (n = 6). Before starting SOF, the HCV viral load and CD4 count were 6.7 log(10) IU/mL (IQR, 5.9-7.2) and 342 cells/mm(3) (IQR, 172-483), respectively. At week 4, the HCV viral load was less than 15 IU/mL in 12 (42.9%) patients. The overall sustained virological response 12 was 96.6%. No significant drug-drug interactions were observed. Conclusions. SOF-based treatment regimens produced excellent results in HIV/HCV coinfected patients after liver transplantation, suggesting an important change in their prognosis.
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收藏
页码:119 / 126
页数:8
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