Characteristic of COVID-19 infection in pediatric patients: early findings from two Italian Pediatric Research Networks

被引：117

作者：

Parri, Niccolo ^{[1
,2
]}

Magista, Anna Maria ^{[3
]}

Marchetti, Federico ^{[4
]}

Cantoni, Barbara ^{[5
]}

Arrighini, Alberto ^{[6
]}

Romanengo, Marta ^{[7
]}

Felici, Enrico ^{[8
]}

Urbino, Antonio ^{[9
]}

Da Dalt, Liviana ^{[10
]}

Verdoni, Lucio ^{[11
]}

Armocida, Benedetta ^{[12
]}

Covi, Benedetta ^{[12
]}

Mariani, Ilaria ^{[12
]}

Giacchero, Roberta ^{[13
]}

Musolino, Anna Maria ^{[14
]}

Binotti, Marco ^{[15
]}

Biban, Paolo ^{[16
]}

Fasoli, Silvia ^{[17
]}

Pilotto, Chiara ^{[18
]}

Nicoloso, Flavia

Raggi, Massimiliano ^{[19
]}

Miorin, Elisabetta ^{[20
]}

Buonsenso, Danilo ^{[21
,22
]}

Chiossi, Massimo ^{[23
]}

Agostiniani, Rino ^{[24
]}

Plebani, Anna ^{[25
]}

Barbieri, Maria Antonietta ^{[14
]}

Lanari, Marcello ^{[26
]}

Arrigo, Serena ^{[27
]}

Zoia, Elena ^{[28
]}

Lenge, Matteo ^{[29
,30
,31
]}

Masi, Stefano ^{[1
,2
]}

Barbi, Egidio ^{[12
,32
]}

Lazzerini, Marzia ^{[12
,33
]}

机构：

[1] Meyer Univ, Dept Emergency Med, Childrens Hosp, Florence, Italy

[2] Meyer Univ, Trauma Ctr, Childrens Hosp, Florence, Italy

[3] Dept Pediat, Community Pediat, Ravenna, Italy

[4] Ravenna Hosp, Dept Pediat, Ravenna, Italy

[5] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Healthcare Profess Dept, Milan, Italy

[6] ASST Spedali Civili, Pediat Emergency Dept, Presidio Osped Bambini, Brescia, Italy

[7] IRCCS Ist Gaslini, Genoa, Italy

[8] Azienda Osped SS Antonio & Biagio & Cesare Arrigo, Pediat & Pediat Emergency Unit, Children Hosp, Alessandria, Italy

[9] AOU Citta Salute & Sci Torino, Regina Margherita Childrens Hosp, Dept Pediat Emergency, Turin, Italy

[10] Univ Padua, Dept Woman & Child Hlth, Pediat Emergency Dept, Padua, Italy

[11] Papa Giovanni XXIII Hosp, Dept Pediat, Bergamo, Italy

[12] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

[13] Lodi Hosp, Dept Pediat, Lodi, Italy

[14] Bambino Gesu Pediat Hosp, Dept Pediat Emergency Med, IRCCS, Rome, Italy

[15] Maggiore della Carta Univ Hosp, Neonatal & Pediat Intens Care Unit, Novara, Italy

[16] Verona Univ Hosp, Dept Neonatal & Paediat Crit Care, Verona, Italy

[17] Carlo Poma Hosp, Paediat Unit, Mantua, Italy

[18] Univ Udine, Acad Hosp Santa Maria della Misericordia, Dept Med DAME, Div Paediat, Udine, Italy

[19] Rovereto Hosp, Pain Therapy Unit, ICU, Trento, Italy

[20] ASUFC, Dept Pediat, Udine, Italy

[21] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy

[22] Univ Cattolica Sacro Cuore, Rome, Italy

[23] ASL 4 Liguria, Dept Pediat, Lavagna, Italy

[24] Osped San Jacopo, Dept Pediat, Pistoia, Italy

[25] Filippo Del Ponte Hosp, Pediat Emergency Unit, ASST Settelaghi, Varese, Italy

[26] Univ Bologna, S Orsola Hosp, Pediat Emergency Unit, Bologna, Italy

[27] Hosp Filippo Del Ponte, Dept Pediat, Varese, Italy

[28] Hosp V Buzzi, Dept Pediat, Milan, Italy

[29] Univ Florence, Childrens Hosp A Meyer, Clin Trial Off, Florence, Italy

[30] Univ Florence, Childrens Hosp A Meyer, Neurosci Dept, Child Neurol Unit & Labs, Florence, Italy

[31] Univ Florence, Childrens Hosp A Meyer, Neurosurg Dept, Funct & Epilepsy Neurosurg Unit, Florence, Italy

[32] Univ Trieste, Dept Med Surg & Hlth Sci, Dept Pediat, Trieste, Italy

[33] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, WHO Collaborating Ctr Maternal & Child Hlth, Via Istria 65-1, I-34137 Trieste, Italy

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2020年 / 179卷 / 08期

关键词：

COVID-19; Children; Adolescents; Italy;

D O I：

10.1007/s00431-020-03683-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Detailed data on clinical presentations and outcomes of children with COVID-19 in Europe are still lacking. In this descriptive study, we report on 130 children with confirmed COVID-19 diagnosed by 28 centers (mostly hospitals), in 10 regions in Italy, during the first months of the pandemic. Among these, 67 (51.5%) had a relative with COVID-19 while 34 (26.2%) had comorbidities, with the most frequent being respiratory, cardiac, or neuromuscular chronic diseases. Overall, 98 (75.4%) had an asymptomatic or mild disease, 11 (8.5%) had moderate disease, 11 (8.5%) had a severe disease, and 9 (6.9%) had a critical presentation with infants below 6 months having significantly increased risk of critical disease severity (OR 5.6, 95% CI 1.3 to 29.1). Seventy-five (57.7%) children were hospitalized, 15 (11.5%) needed some respiratory support, and nine (6.9%) were treated in an intensive care unit. All recovered. Conclusion:This descriptive case series of children with COVID-19, mostly encompassing of cases enrolled at hospital level, suggest that COVID-19 may have a non-negligible rate of severe presentations in selected pediatric populations with a relatively high rates of comorbidities. More studies are needed to further understand the presentation and outcomes of children with COVID-19 in children with special needs.

引用

页码：1315 / 1323

页数：9

共 16 条

[1]

[Anonymous], 2020, MMWR Morb Mortal Wkly Rep

[2] Additional Concerns Regarding Children With Coronavirus Disease 2019-Reply [J].

Castagnoli, Riccardo ;

Licari, Amelia ;

Marseglia, Gian Luigi .

JAMA PEDIATRICS, 2020, 174 (12) :1218-1219

[3] Geographic Differences in COVID-19 Cases, Deaths, and Incidence - United States, February 12-April 7, 2020 [J].

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (15) :465-471

[4] Clinical profiles and diagnostic challenges in 1158 children with rare hepatobiliary disorders [J].

Dong, Yi ;

Wang, Jian ;

Zhu, Shishu ;

Zheng, Huanwei ;

Wang, Chunya ;

Zhao, Pan .

PEDIATRIC RESEARCH, 2021, 89 (01) :238-245

[5] Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response [J].

Grasselli, Giacomo ;

Pesenti, Antonio ;

Cecconi, Maurizio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1545-1546

[6]

Istituto superiore di sanita, EP COVID 19 AGG NAZ

[7]

Maxmen Amy, 2020, Nature, DOI 10.1038/d41586-020-00760-8

[8]

*MIN SAL, CIRC 9 MARCH 2020

[9]

PARRI N, 2020, NEJM

[10] Cutaneous manifestations in COVID-19: a first perspective [J].

Recalcati, S. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (05) :E212-E213

← 1 2 →