Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report

被引：9

作者：

Lindner, Andrea Katharina ^{[1
]}

Schachtner, Gert ^{[1
]}

Tulchiner, Gennadi ^{[1
]}

Staudacher, Nina ^{[1
]}

Steinkohl, Fabian ^{[2
]}

Nguyen, Van Anh ^{[3
]}

Horninger, Wolfgang ^{[1
]}

Pichler, Renate ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Urol, Anichstr 35, Innsbruck, Austria

[2] Dept Radiol, Anichstr 35, Innsbruck, Austria

[3] Dept Dermatol Venereol & Allergy, Anichstr 35, Innsbruck, Austria

来源：

UROLOGY CASE REPORTS | 2019年 / 23卷

关键词：

Renal cell cancer; Nivolumab; Lichen ruber; Side effects; Cutaneous adverse event;

D O I：

10.1016/j.eucr.2018.11.008

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Nivolumab belongs to the standard treatment options in metastatic renal cell carcinoma. Despite promising responses, a new spectrum of "immune-related" adverse effects has to be managed in daily clinical practice. A 74-year-old patient was treated with nivolumab in fourth-line. After 18 cycles, treatment was stopped due to severe adverse mucocutaneous reactions confirming a lichen ruber pemphigoides. CT scans during treatment discontinuation show stable disease since more than 14 months. Immunotherapy can cause mucocutaneous immune-mediated adverse reactions. The time of onset to cutaneous adverse effects is variable. Early recognition and treatment are essential in mitigating the severity of those adverse events.

引用

页码：1 / 2

页数：2

共 5 条

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