Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF

被引：55

作者：

Malmestrom, Clas ^{[2
]}

Lycke, Jan ^{[2
]}

Haghighi, Sara ^{[2
]}

Andersen, Oluf ^{[2
]}

Carlsson, Lena ^{[1
]}

Wadenvik, Hans ^{[1
]}

Olsson, Bob ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Internal Med, Sahlgrenska Acad, SE-41345 Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrens Univ Hosp, Sahlgrenska Acad, Dept Neurol, SE-41345 Gothenburg, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 196卷 / 1-2期

关键词：

multiple sclerosis; T-cells; T-cell mediated cytotoxicity; microarray; granzymes;

D O I：

10.1016/j.jneuroim.2008.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the, CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses. (C) 2008 Elsevier B.V. All rights reserved.

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收藏

页码：159 / 165

页数：7

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