Plant-based anticancer molecules: A chemical and biological profile of some important leads

被引：283

作者：

Srivastava, V ^{[1
]}

Negi, AS ^{[1
]}

Kumar, JK ^{[1
]}

Gupta, MM ^{[1
]}

Khanuja, SPS ^{[1
]}

机构：

[1] CIMAP, Lucknow 226015, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 21期

关键词：

anticancer; camptothecin; taxol; combretastatin A4; podophyllotoxin;

D O I：

10.1016/j.bmc.2005.05.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of natural products, with diverse chemical structures, have been isolated as anticancer agents. Several potential lead molecules such as camptothecin, vincristine, vinblastine, taxol, podophyllotoxin, combretastatins, etc. have been isolated from plants and many of them have been modified to yield better analogues for activity, toxicity or solubility. Several successful molecules like topotecan, irinotecan, taxotere, etoposide, teniposide, etc. also have emerged as drugs upon modification of these natural leads and many more are yet to come. In this review, the authors have focused on four important anticancer leads, that is, camptothecin, taxol, combretastatin A-4 and podophyllotoxin. Their chemistry, structure and activity relationships, biological activities, modes of action, analogue synthesis and future prospects have been discussed. (c) 2005 Published by Elsevier Ltd.

引用

页码：5892 / 5908

页数：17

共 104 条

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