Severe skin inflammation leads to salivary gland atrophy and dysfunction

被引：6

作者：

Matsushima, Yoshiaki ^{[1
]}

Mizutani, Kento ^{[1
]}

Iida, Shohei ^{[1
]}

Ichishi, Masako ^{[2
]}

Nakanishi, Takehisa ^{[1
]}

Okada, Karin ^{[1
]}

Umaoka, Ai ^{[1
]}

Kondo, Makoto ^{[1
]}

Habe, Koji ^{[1
]}

Watanabe, Masatoshi ^{[2
]}

Yamanaka, Keiichi ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Dermatol, Tsu, Mie 5148507, Japan

[2] Mie Univ, Grad Sch Med, Oncol Pathol, Tsu, Mie, Japan

来源：

JOURNAL OF DERMATOLOGY | 2022年 / 49卷 / 06期

关键词：

cytokine; dry mouth; inflammatory skin disease; saliva; systemic inflammation; ATOPIC-DERMATITIS; PSORIASIS; RISK;

D O I：

10.1111/1346-8138.16334

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis and atopic dermatitis are inflammatory skin diseases, and these patients have an increased risk of cardiovascular events and other medical complications. It has been clarified that skin inflammation affects internal organs. Additionally, dental caries tends to occur more frequently in patients with psoriasis and atopic dermatitis. In this study, we aim to investigate the effects of dermatitis on the salivary glands using an inflammation model mouse. Salivary secretion stimulated with pilocarpine was reduced in dermatitis mice. Histologically, dermatitis mice showed amyloid deposition, glandular atrophy, and fibrosis in the salivary glands. Expression of inflammatory cytokines in the salivary glands was higher in dermatitis mice; however, secretion of cytokines in saliva was not significantly different. Dermatitis mice showed decreased salivary secretion and histological changes, which may cause periodontal disease. Therefore, appropriate control of skin inflammation is essential.

引用

页码：642 / 647

页数：6

共 15 条

[1] Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the UK [J].

Abuabara, K. ;

Azfar, R. S. ;

Shin, D. B. ;

Neimann, A. L. ;

Troxel, A. B. ;

Gelfand, J. M. .

BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (03) :586-592

[2] Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ [J].

Bardow, A ;

Nyvad, B ;

Nauntofte, B .

ARCHIVES OF ORAL BIOLOGY, 2001, 46 (05) :413-423

[3] Associations Between Salivary Gland Histopathologic Diagnoses and Phenotypic Features of Sjogren's Syndrome Among 1,726 Registry Participants [J].

Daniels, Troy E. ;

Cox, Darren ;

Shiboski, Caroline H. ;

Schiodt, Morten ;

Wu, Ava ;

Lanfranchi, Hector ;

Umehara, Hisanori ;

Zhao, Yan ;

Challacombe, Stephen ;

Lam, Mi Y. ;

De Souza, Yvonne ;

Schiodt, Julie ;

Holm, Helena ;

Bisio, Patricia A. M. ;

Gandolfo, Mariana S. ;

Sawaki, Toshioki ;

Li, Mengtao ;

Zhang, Wen ;

Varghese-Jacob, Beni ;

Ibsen, Per ;

Keszler, Alicia ;

Kurose, Nozomu ;

Nojima, Takayuki ;

Odell, Edward ;

Criswell, Lindsey A. ;

Jordan, Richard ;

Greenspan, John S. .

ARTHRITIS AND RHEUMATISM, 2011, 63 (07) :2021-2030

[4] Odontogenic focal infection could be partly involved in the pathogenesis of atopic dermatitis as exacerbating factor [J].

Igawa, Ken ;

Nishioka, Kiyoshi ;

Yokozeki, Hiroo .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2007, 46 (04) :376-379

[5] Janus Kinase Inhibitors Ameliorated Gastrointestinal Amyloidosis and Hypoalbuminemia in Persistent Dermatitis Mouse Model [J].

Nakanishi, Takehisa ;

Mizutani, Kento ;

Iida, Shohei ;

Matsushima, Yoshiaki ;

Umaoka, Ai ;

Kondo, Makoto ;

Habe, Koji ;

Yamanaka, Keiichi .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (01)

[6] Periodontal disease and risk of psoriasis among nurses in the United States [J].

Nakib, Sarah ;

Han, Jiali ;

Li, Tricia ;

Joshipura, Kaumudi ;

Qureshi, Abrar A. .

ACTA ODONTOLOGICA SCANDINAVICA, 2013, 71 (06) :1423-1429

[7] AA amyloidosis: basic knowledge, unmet needs and future treatments [J].

Obici, Laura ;

Merlini, Giampaolo .

SWISS MEDICAL WEEKLY, 2012, 142

[8] Salivary changes and dental caries as potential oral markers of autoimmune salivary gland dysfunction in primary Sjogren's syndrome [J].

Pedersen, Anne ;

Bardow, Allan ;

Nauntofte, Birgitte .

BMC CLINICAL PATHOLOGY, 2005, 5

[9] The physiology of salivary secretion [J].

Proctor, Gordon B. .

PERIODONTOLOGY 2000, 2016, 70 (01) :11-25

[10] Psoriasis and infection. A clinical practice narrative [J].

Rademaker, Marius ;

Agnew, Karen ;

Anagnostou, Nicholas ;

Andrews, Megan ;

Armour, Katherine ;

Baker, Christopher ;

Foley, Peter ;

Gebauer, Kurt ;

Gupta, Monisha ;

Marshman, Gillian ;

Rubel, Diana ;

Sullivan, John ;

Wong, Li-Chuen .

AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2019, 60 (02) :91-98

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