Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins

被引：39
作者：
Chohan, ZH
Pervez, H
Khan, KM
Rauf, A
Maharvi, GM
Supuran, CT
机构：
[1] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Florence, Italy
[2] Bahauddin Zakariya Univ, Dept Chem, Multan, Pakistan
[3] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[4] Islamia Univ, Dept Chem, Bahawalpur, Pakistan
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 01期
关键词：
cephalexin; Schiff's bases; transition metal complexes; antifungal activity;
D O I：
10.1080/14756360310001650183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes have been synthesized and studied for their antifungal properties against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active.
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页码：85 / 90
页数：6
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