Biosensing with Fluorescent Carbon Nanotubes

被引：167

作者：

Ackermann, Julia ^{[2
,3
]}

Metternich, Justus T. ^{[1
,2
]}

Herbertz, Svenja ^{[2
]}

Kruss, Sebastian ^{[1
,2
]}

机构：

[1] Ruhr Univ Bochum, Phys Chem, Univ Str 150, D-44801 Bochum, Germany

[2] Fraunhofer Inst Microelect Circuits & Syst, Biomed Nanosensors, Finkenstr 61, D-47057 Duisburg, Germany

[3] Univ Duisburg Essen, Dept EBS, Bismarckstr 81, D-47057 Duisburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 18期

关键词：

biosensors; carbon nanotubes; imaging; molecular recognition; near-infrared fluorescence; PHASE MOLECULAR RECOGNITION; NEAR-INFRARED PHOTOLUMINESCENCE; DNA CONFORMATIONAL POLYMORPHISM; BAND-GAP FLUORESCENCE; SINGLE-STRANDED-DNA; OPTICAL SENSORS; NONCOVALENT FUNCTIONALIZATION; SELECTIVE DISPERSION; PROTEIN-DETECTION; SEPARATION;

D O I：

10.1002/anie.202112372

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biosensors are powerful tools for modern basic research and biomedical diagnostics. Their development requires substantial input from the chemical sciences. Sensors or probes with an optical readout, such as fluorescence, offer rapid, minimally invasive sensing of analytes with high spatial and temporal resolution. The near-infrared (NIR) region is beneficial because of the reduced background and scattering of biological samples (tissue transparency window) in this range. In this context, single-walled carbon nanotubes (SWCNTs) have emerged as versatile NIR fluorescent building blocks for biosensors. Here, we provide an overview of advances in SWCNT-based NIR fluorescent molecular sensors. We focus on chemical design strategies for diverse analytes and summarize insights into the photophysics and molecular recognition. Furthermore, different application areas are discussed-from chemical imaging of cellular systems and diagnostics to in vivo applications and perspectives for the future.

引用

页数：50

共 255 条

[81] Non-covalent Methods of Engineering Optical Sensors Based on Single-Walled Carbon Nanotubes [J].