Synthesis of C3-Cyanomethylated Imidazo[1,2-a]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst-and Oxidant-Free Conditions

被引：4

作者：

Zhang, Jie ^{[1
]}

Zhang, Yufeng ^{[1
]}

Zhang, Jian ^{[1
]}

Wu, Qingguo ^{[1
]}

Yang, Haifeng ^{[1
]}

机构：

[1] Jiangsu Agrianim Husb Vocat Coll, Sch Anim Pharmaceut Sci, Taizhou 225300, Peoples R China

来源：

SYNLETT | 2022年 / 33卷 / 03期

关键词：

ultrasonic irradiation; three-component reaction; cyanomethylation; imidazopyridines; catalyst- and oxidant-free; VISIBLE-LIGHT; MULTICOMPONENT REACTIONS; GREEN SYNTHESIS; PALLADIUM NANOPARTICLES; ANNULATED PYRIDINES; EFFICIENT; IMIDAZOPYRIDINES; CHEMISTRY; 2-AMINOPYRIDINES; ACTIVATION;

D O I：

10.1055/a-1704-4822

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of C3-cyanomethylated imidazo[1,2-a]pyridiries via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free, and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-a]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

引用

页码：264 / 268

页数：5

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