Smoking worsens multiple sclerosis prognosis: Two different pathways are involved

被引：44

作者：

Correale, Jorge ^{[1
]}

Farez, Mauricio F. ^{[1
]}

机构：

[1] FLENI, Dept Neurol, Inst Neurol Res Dr Raul Carrea, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 281卷

关键词：

Multiple sclerosis; Smoking; Indoleamine 2,3-dioxygenase; Renin-angiotensin-system; RENIN-ANGIOTENSIN SYSTEM; REGULATORY T-CELLS; CIGARETTE-SMOKING; INDOLEAMINE 2,3-DIOXYGENASE; TOBACCO SMOKING; DENDRITIC CELLS; RISK; PROGRESSION; TRYPTOPHAN; INFLAMMATION;

D O I：

10.1016/j.jneuroim.2015.03.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Smoking worsens multiple sclerosis (MS) prognosis. Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6 and IL-13. Additionally, both degree of expression and renin-angiotensin system activity levels were increased in MS patients who smoked, inducing increase in IL-17 and IL-22-producing cell numbers as well as significantly greater production of CCL2, CCL3 and CXCL10 chemokines by monocytes. Finally, both pathways contributed to a significant decrease in the number of CD4+CD25+FoxP3 + regulatory T cells in MS patients who smoked. Both pathways could be responsible for the association between smoking and MS risk. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：23 / 34

页数：12

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