Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus

被引：23

作者：

Hodak, E ^{[1
]}

Lapidoth, M

David, M

机构：

[1] Rabin Med Ctr, Dept Dermatol, Beilinson Campus, IL-49100 Petah Tiqwa, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1999年 / 40卷 / 01期

关键词：

D O I：

10.1016/S0190-9622(99)70533-5

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutrophils, making colchicine a reasonable pharmacologic option for treatment. Objective: We attempted to determine the efficacy of colchicine in the treatment of SPD-type IgA pemphigus. Methods: Two patients with SPD-type IgA pemphigus were treated with colchicine 1.5 mg/day as monotherapy. Results: A sustained clinical response was achieved within 2 to 3 weeks of therapy. Relapses were noted each time colchicine was stopped. Conclusion: Colchicine should be considered in the treatment of SPD-type IgA pemphigus.

引用

页码：91 / 94

页数：4

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