A DPA-based highly selective and sensitive fluorescent probe for mercuric ions and its imaging in living cells

被引：13
作者：
Jia, Junhua [1 ]
Wu, Luling [2 ,3 ]
Ding, Yu [1 ]
Huang, Chusen [2 ,3 ]
Zhu, Weiping [1 ]
Xu, Yufang [1 ]
Qian, Xuhong [1 ]
机构：
[1] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Shanghai Normal Univ, Educ Minist, Key Lab Resource Chem, 100 Guilin Rd, Shanghai 200234, Peoples R China
[3] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Dept Hemistry, Coll Life & Environm Sci, 100 Guilin Rd, Shanghai 200234, Peoples R China
来源：
DALTON TRANSACTIONS | 2016年 / 45卷 / 23期
基金：
中国国家自然科学基金;
关键词：
PHOTOINDUCED ELECTRON-TRANSFER; AQUEOUS-MEDIA; ZINC IONS; DETECTING HG2+; LIVE CELLS; SENSOR; WATER; RHODAMINE; RECOGNITION; CU2+;
D O I：
10.1039/c6dt01258b
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Based on the 2,2-dipicolylamine (DPA) receptor and naphthalimide fluorophore, three fluorescent probes, RDPA, MDPA and VDPA have been developed for the recognition of mercuric ions. Among them, VDPA, bearing a diglycol group in the imine chain, exhibits good water solubility, and high selectivity towards mercuric ions in PBS water solution. With DPA as the receptor, VDPA showed very high affinity and sensitivity towards He2+, and the binding constant and detection limit were calculated to be 2.8 x 10(10) M-1 and 5.49 nM, respectively. The MTT assay and living cell imaging experiments suggested that the probe VDPA has potential application for detecting Hg2+ in living cells.
引用
收藏
页码：9402 / 9406
页数：5
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