Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)

被引：5

作者：

Ibrahim, Madiha Salah ^{[1
,2
]}

Watanabe, Yohei ^{[1
]}

Ellakany, H. F. ^{[3
]}

Yamagishi, Aki ^{[1
]}

Sapsutthipas, Sompong ^{[1
]}

Toyoda, Tetsuya ^{[4
]}

El-Hamied, H. S. Abd ^{[5
]}

Ikuta, Kazuyoshi ^{[1
]}

机构：

[1] Osaka Univ, Dept Virol, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[2] Damanhour Univ, Dept Microbiol, Fac Vet Med, Damanhour, Egypt

[3] Univ Alexandria, Fac Vet Med, Dept Poultry Dis & Hyg, Alexandria, Egypt

[4] Inst Pasteur Shanghai, Unit Viral Genome Regulat, Shanghai, Peoples R China

[5] Damanhour Univ, Dept Poultry Dis & Hyg, Fac Vet Med, Damanhour, Egypt

来源：

VIRUS GENES | 2011年 / 42卷 / 03期

关键词：

H5N1; Sequencing; Phylogeny; Egypt; MOLECULAR CHARACTERIZATION; A-VIRUS; OUTBREAKS; POULTRY;

D O I：

10.1007/s11262-011-0583-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The complete genome sequences of two isolates A/chicken/Egypt/CL6/07 (CL6/07) and A/duck/Egypt/D2br10/07 (D2br10/07) of highly pathogenic avian influenza virus (HPAI) H5N1 isolated at the beginning of 2007 outbreak in Egypt were determined and compared with all Egyptian HPAI H5N1 sequences available in the GenBank. Sequence analysis utilizing the RNA from the original tissue homogenate showed amino acid substitutions in seven of the viral segments in both samples. Interestingly, these changes were different between the CL6/07 and D2br10/07 when compared to other Egyptian isolates. Moreover, phylogenetic analysis showed independent sub-clustering of the two viruses within the Egyptian sequences signifying a possible differential adaptation in the two hosts. Further, pre-amplification analysis of H5N1 might be necessary for accurate data interpretation and identification of distinct factor(s) influencing the evolution of the virus in different poultry species.

引用

页码：363 / 368

页数：6

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