Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

被引:21
作者
Bear, Joseph C. [1 ]
Patrick, P. Stephen [2 ,3 ]
Casson, Alfred [1 ]
Southern, Paul [4 ]
Lin, Fang-Yu [4 ]
Powell, Michael J. [1 ]
Pankhurst, Quentin A. [4 ,5 ]
Kalber, Tammy [2 ,3 ]
Lythgoe, Mark [2 ,3 ]
Parkin, Ivan P. [1 ]
Mayes, Andrew G. [6 ]
机构
[1] UCL, Dept Chem, Mat Chem Ctr, 20 Gordon St, London WC1H 0AJ, England
[2] UCL, Dept Med, CABI, London WC1E 6DD, England
[3] UCL, Inst Child Hlth, London WC1E 6DD, England
[4] Royal Inst Great Britain, UCL Healthcare Biomagnet Labs, 21 Albemarle St, London W1S 4BS, England
[5] UCL, Inst Biomed Engn, London WC1E 6BT, England
[6] Univ East Anglia, Sch Chem, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England
基金
英国工程与自然科学研究理事会; 英国医学研究理事会;
关键词
DELIVERY-SYSTEMS; TRIGGERED RELEASE; ON-DEMAND; NANOTECHNOLOGY; LAXATIVES; NANOPARTICLES; LIMITATIONS; DIAGNOSIS; THERAPIES; POLYMERS;
D O I
10.1038/srep34271
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug-delivery vehicle must experience before it releases it's drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane-superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.
引用
收藏
页数:11
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