Phase Separation in Lipid Membranes

被引：166

作者：

Heberle, Frederick A. ^{[1
]}

Feigenson, Gerald W. ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Field Biophys, Ithaca, NY 14853 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2011年 / 3卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PLASMA-MEMBRANES; MOLECULAR-INTERACTIONS; MODEL BIOMEMBRANES; TERNARY MIXTURES; DOMAIN FORMATION; CHOLESTEROL; BILAYERS; VESICLES; RAFTS; PHOSPHATIDYLCHOLINE;

D O I：

10.1101/cshperspect.a004630

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell membranes show complex behavior, in part because of the large number of different components that interact with each other in different ways. One aspect of this complex behavior is lateral organization of components on a range of spatial scales. We found that lipid-only mixtures can model the range of size scales, from approximately 2 nm up to microns. Furthermore, the size of compositional heterogeneities can be controlled entirely by lipid composition for mixtures such as 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)/cholesterol or sphingomyelin (SM)/DOPC/POPC/cholesterol. In one region of special interest, because of its connection to cell membrane rafts, nanometer-scale domains of liquid-disordered phase and liquid-ordered phase coexist over a wide range of compositions.

引用

页码：1 / 13

页数：13

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