A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis

被引：37
作者：
Luomala, M
Lehtimäki, T
Elovaara, I
Wang, XY
Ukkonen, M
Mattila, K
Laippala, P
Koivula, T
Hurme, M
机构：
[1] Tampere Univ Hosp, Ctr Lab Med, Dept Clin Chem, Lab Atherosclerosis Genet, Tampere 33521, Finland
[2] Univ Tampere, Grad Sch Biosci, Int Programme Neurosci, FIN-33101 Tampere, Finland
[3] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland
[4] Tampere Univ Hosp, Dept Neurol, Neuroimmunol Unit, FIN-33101 Tampere, Finland
[5] Univ Tampere, Dept Microbiol & Immunol, FIN-33101 Tampere, Finland
[6] Tampere Sch Publ Hlth, Tampere, Finland
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2001年 / 185卷 / 02期
关键词：
interleukin-1; IL-1 receptor antagonist; multiple sclerosis; susceptibility; severity; gender;
D O I：
10.1016/S0022-510X(01)00482-8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this explorative study. interleukin-1 (IL-1) receptor antagonist (IL-1RA; polymorphism of variable number of tandem repeats: VNTR), IL-1 alpha ( - 889), IL-1 beta (- 511) and IL-1 beta (+ 3953) polymorphisms were studied in relation to susceptibility to and severity of multiple sclerosis (MS), in 93 MS patients and 400 normal controls. No associations were found for any polymorphisms, alone or in combination. However, in our MS cohort, females were found to be IL-1RA allele 2 carriers more frequently than males (33/49 vs. 16/44, p = 0.0028). Using a cohort of 109 controls, IL-1RA allele 2 carriers were more frequently women with MS than control women (33/49 vs. 23/43, odds ratio (OR)= 2.19, 95% confidence interval (CI) 1.02-3.72, p = 0.043, P-C = ns). The data suggest that the IL-1 cluster genes make no major contribution to MS, but the tentative association between IL-1RA allele 2 and susceptibility of MS in women warrants further studies. (C) 2001 Elsevier Science B.V. All rights reserrved.
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页码：123 / 127
页数：5
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