The IL-10 Promoter Polymorphism at Position-592 is Correlated with Susceptibility to Occult HBV Infection

被引：38

作者：

Ahmadabadi, Behzad Nasiri ^{[1
,2
]}

Hassanshahi, Gholamhossein ^{[1
,2
]}

Arababadi, Mohammad Kazemi ^{[1
,2
]}

Leanza, Cristiana ^{[3
]}

Kennedy, Derek ^{[3
]}

机构：

[1] Rafsanjan Univ Med Sci, Dept Microbiol & Immunol, Fac Med, Rafsanjan, Iran

[2] Rafsanjan Univ Med Sci, Mol Med Res Ctr, Rafsanjan, Iran

[3] Griffith Univ, Sch Biomol & Phys Sci, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

来源：

INFLAMMATION | 2012年 / 35卷 / 03期

关键词：

occult hepatitis B infection; IL-10; polymorphism; HBsAg; HBV-DNA; HEPATITIS-B; INTERLEUKIN-10; CYTOKINES;

D O I：

10.1007/s10753-011-9381-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Occult hepatitis B infection (OBI) is characterized as a form of hepatitis in which detectable amounts of HBV-DNA can be monitored in the peripheral blood of patients whereas the hepatitis B surface antigen is undetectable. The main aim of this study was to investigate whether there is a relationship between OBI and single nucleotide polymorphisms in the -592 region of the IL-10 gene. In this study, the polymorphism at position -592 of the IL-10 promoter of 57 OBI cases was compared and correlated to that of 100 healthy controls by PCR-RFLP techniques. Our results showed that patient and control groups had significant differences regarding genotypes and alleles of the -592 polymorphism in the IL-10 gene. Based on our results, it can be concluded that the -592 polymorphism within the promoter of the IL-10 gene is associated with OBI.

引用

页码：818 / 821

页数：4

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