Biomolecular interactions and tools for their recognition: focus on the quartz crystal microbalance and its diverse surface chemistries and applications

被引:189
作者
Cheng, Cathy I. [1 ,2 ]
Chang, Yi-Pin [3 ]
Chu, Yen-Ho [1 ]
机构
[1] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 62102, Taiwan
[2] Univ Calif Davis Hlth Syst, Dept Internal Med, Sacramento, CA 95817 USA
[3] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England
关键词
SELF-ASSEMBLED MONOLAYERS; AFFINITY CAPILLARY-ELECTROPHORESIS; ACOUSTIC-WAVE SENSOR; ISOTHERMAL TITRATION CALORIMETRY; ATP-DEPENDENT DEOXYRIBONUCLEASE; LATEX PIEZOELECTRIC IMMUNOASSAY; ECORV RESTRICTION-ENDONUCLEASE; DNA-POLYMERASE REACTIONS; DRUG-PROTEIN BINDING; ANTIBODY IMMOBILIZATION;
D O I
10.1039/c1cs15168a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Interactions between molecules are ubiquitous and occur in our bodies, the food we eat, the air we breathe, and myriad additional contexts. Although numerous tools are available for the recognition of biomolecular interactions, such tools are often limited in their sensitivity, expensive, and difficult to modify for various uses. In contrast, the quartz crystal microbalance (QCM) has sub-nanogram detection capabilities, is label-free, is inexpensive to create, and can be readily modified with a number of diverse surface chemistries to detect and characterize diverse interactions. To maximize the versatility of the QCM, scientists need to know available methods by which QCM surfaces can be modified. Therefore, in addition to summarizing the various tools currently used for biomolecular recognition, explicating the fundamental principles of the QCM as a tool for biomolecular recognition, and comparing the QCM with other acoustic sensors, we systematically review the numerous types of surface chemistries-including hydrophobic bonds, ionic bonds, hydrogen bonds, self-assembled monolayers, plasma-polymerized films, photochemistry, and sensing ionic liquids-used to functionalize QCMs for various purposes. We also review the QCM's diverse applications, which include the detection of gaseous species, detection of carbohydrates, detection of nucleic acids, detection of non-enzymatic proteins, characterization of enzymatic activity, detection of antigens and antibodies, detection of cells, and detection of drugs. Finally, we discuss the ultimate goals of and potential barriers to the development of future QCMs.
引用
收藏
页码:1947 / 1971
页数:25
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