On the edge of validation - Cancer protease fibroblast activation protein

被引：31

作者：

Wolf, Beni B. ^{[1
,2
,3
]}

Quan, Clifford ^{[1
,2
,3
]}

Tran, Thuy ^{[1
,2
,3
]}

Wiesmann, Christian ^{[1
,2
,3
]}

Sutherlin, Daniel ^{[1
,2
,3
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA

[3] Genentech Inc, Dept Med Chem, San Francisco, CA 94080 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 07期

关键词：

FAP; DPP4; dipeptidyl peptidase; prolyl peptidase; inhibitor; cancer;

D O I：

10.2174/138955708784567449

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed at validating and inhibiting FAP for cancer therapy and highlight future directions for successful targeting of this prolyl peptidase.

引用

页码：719 / 727

页数：9

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